glutathione S-transferase mu (GSTM) 억제제

GSTM, or glutathione S-transferase mu, is part of the GST family of enzymes that are key players in cellular detoxification processes. These enzymes catalyze the conjugation of glutathione, a critical antioxidant, to various substrates, including xenobiotics, drugs, and products of oxidative stress. GSTM enzymes are particularly important in the metabolism and detoxification of carcinogens, and their activity can influence the cellular response to oxidative stress and chemical insults. The expression of GSTM enzymes is often upregulated in response to oxidative stress and in various pathological conditions, including cancer. By facilitating the conjugation of glutathione to reactive intermediates, GSTM enzymes help in neutralizing toxins and protecting cells from damage.

Targeting GSTM for disruption or inhibition has been explored mainly in the context, as these enzymes can contribute to drug resistance and tumor survival. Inhibitors of GSTM are designed to increase the sensitivity of cancer cells to the detoxification of agents. However, the challenge in targeting GSTM lies in achieving specificity, as inhibiting these enzymes can also disrupt normal cellular detoxification processes, leading to increased susceptibility to oxidative stress and toxicity.