Date published: 2026-4-23

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CatSper Inhibitors

CatSper inhibitors are a specific class of chemical compounds that target a crucial protein known as CatSper (Cation channel of Sperm). CatSper is primarily found in the sperm cells of mammals, where it plays a vital role in regulating sperm motility and function. These inhibitors interact with the CatSper channel and modulate its activity, effectively reducing the influx of certain ions, such as calcium, into the sperm cells. By doing so, they hinder the normal physiological processes involved in sperm activation and fertilization. The exact mechanisms through which CatSper inhibitors exert their effects are complex and involve intricate cellular signaling pathways. These inhibitors have garnered significant interest in scientific research due to their potential to disrupt sperm function and interfere with fertility. Understanding the molecular interactions of CatSper inhibitors provides valuable insights into the mechanisms underlying sperm motility and fertilization, thereby shedding light on the fundamental processes of reproduction. Researchers have been exploring the effects of these inhibitors in various experimental settings to gain a comprehensive understanding of their impact on sperm physiology. Additionally, investigating CatSper inhibitors may pave the way for the development of novel approaches for contraception or fertility control, though this area of application remains purely speculative at this stage of research. Nevertheless, these compounds hold immense promise for further studies and have the potential to contribute to our understanding of reproductive biology and sperm-related processes.
Product NameCAS #Catalog #QUANTITYPriceCitationsRATING

Nifedipine

21829-25-4sc-3589
sc-3589A
1 g
5 g
$59.00
$173.00
15
(1)

Nifedipine is a calcium channel blocker that has been studied for its potential to inhibit Catsper by reducing intracellular calcium levels in sperm cells.

Spiperone

749-02-0sc-471047
250 mg
$130.00
(0)

Spiperone is a compound that has been investigated for its inhibitory effects on Catsper channels in sperm cells.

NNC 55-0396

357400-13-6sc-203647A
sc-203647
5 mg
10 mg
$250.00
$421.00
2
(1)

NNC 55-0396 is a compound that targets voltage-gated calcium channels, including Catsper..

Trospium Chloride

10405-02-4sc-208473
25 mg
$260.00
2
(0)

This compound achieves its inhibitory effect through a mechanism that likely involves the blockade of the CatSper channel or the alteration of the channel's ion permeability, thereby hindering the influx of calcium ions essential for the activation of sperm motility and other related processes.