Molecular structure of ZM-306416, CAS Number: 690206-97-4
ZM-306416 (CAS 690206-97-4)
Application:
ZM-306416 is a receptor tyrosine kinase inhibitor that has been shown to disrupt Flt and Flk activity
CAS Number:
690206-97-4
Molecular Weight:
333.7
Molecular Formula:
C16H13ClFN3O2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Description
Technical Information
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SDS & Certificate of Analysis
ZM-306416 is a VEGF receptor tyrosine kinase inhibitor that inhibits Flk-1 (KDR) (IC50 = 100 nM) and Flt (IC50 = 2 µM) tyrosine kinases. This product has been shown to display approximately 4-fold selectivity over FGFR-1. ZM-306416 is an inhibitor of c-Abl, Flt-1 and SRC.
ZM-306416 (CAS 690206-97-4) References
- Design and structure-activity relationship of a new class of potent VEGF receptor tyrosine kinase inhibitors. | Hennequin, LF., et al. 1999. J Med Chem. 42: 5369-89. PMID: 10639280
- Optimization of 4-phenylamino-3-quinolinecarbonitriles as potent inhibitors of Src kinase activity. | Boschelli, DH., et al. 2001. J Med Chem. 44: 3965-77. PMID: 11689083
- A high-content biosensor-based screen identifies cell-permeable activators and inhibitors of EGFR function: implications in drug discovery. | Antczak, C., et al. 2012. J Biomol Screen. 17: 885-99. PMID: 22573732
- Decreased PGF may contribute to trophoblast dysfunction in fetal growth restriction. | Wu, WB., et al. 2017. Reproduction. 154: 319-329. PMID: 28676532
- Multi-Omics Immune Interaction Networks in Lung Cancer Tumorigenesis, Proliferation, and Survival. | Ye, Q., et al. 2022. Int J Mol Sci. 23: PMID: 36499305
Inhibitor of:
c-Abl, Flk-1, Flt-1, and SRC.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
ZM-306416, 1 mg | sc-200676 | 1 mg | $75.00 | |||
ZM-306416, 10 mg | sc-200676A | 10 mg | $152.00 |