Zinquin, Free Acid CAS: 151606-29-0
MF: C19H18N2O5S
MW: 386.42
A Zn2+ specific fluorophore that forms zinquin-Zn2+ complexes.

Zinquin, Free Acid (CAS 151606-29-0)

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別名: (2-Methyl-8-p-toluenesulfonamido-6-quinolyloxy)acetic acid
アプリケーション: Zinquin, Free Acid is a Zn2+ specific fluorophore that forms zinquin-Zn2+ complexes
CAS 番号: 151606-29-0
Purity: ≥98%
Molecular Weight: 386.42
Molecular Formula: C19H18N2O5S
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* Refer to Certificate of Analysis for lot specific data (including water content).
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Zinquin, Free Acid is a Zn2+ specific fluorophore that forms zinquin-Zn2+ complexes in either 1:1 or 2:1 ratios (Kd of 370 ± 60 nM and 850 ± 160 nM, respectively). Intracellular zinc mobilization has been shown to be an early indicator of apoptosis. As a zinc probe, it is UV-excitable and emits in the blue region of the spectrum.


参考文献

Brand, I.A., and Kleineke, J. 1996. J. Biol. Chem. 271, 1941. Zalewski, P.D., et al. 1994. Chem. Biol. 1, 153. Zalewski, P.D., et al. 1993. Biochem. J. 296, 403.

Physical State :
Solid
Solubility :
Soluble in DMSO, and methanol.
保存方法 :
Store at -20° C
Melting Point :
250.05° C
Boiling Point :
608.00° C at 760 mmHg
Density :
1.41 g/cm3
Refractive Index :
n20D 1.66
Fluoresence :
λex 364 nm, λem 485 nm
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
WGK Germany :
3
PubChem CID :
Merck Index :
14: 10169
MDL Number :
MFCD03452711
SMILES :
CC1=CC=C(C=C1)S(=O)(=O)NC2=C3C(=CC(=C2)OCC(=O)O)C=CC(=N3)C

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Zinquin, Free Acid (CAS 151606-29-0)  参考文献

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PMID: # 28794468  Dambal, S.|Baumann, B.|McCray, T.|Williams, L.|Richards, Z.|Deaton, R.|Prins, GS.|Nonn, L.| et al. 2017. Sci Rep. 7: 7704.

引用 1 to 1 of 1 合計
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