Vinclozolin M2 (CAS 83792-61-4)

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別名: 3′,5′-Dichloro-2-hydroxy-2-methylbut-3-enanilide

アプリケーション： Vinclozolin M2 is a dicarboximide fungicide

CAS 番号: 83792-61-4

Molecular Weight: 260.12

Molecular Formula: C₁₁H₁₁Cl₂NO₂

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* Refer to Certificate of Analysis for lot specific data (including water content).

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Vinclozolin M2 and M1 are metabolites of vinclozolin, a dicarboximide fungicide widely used in the United States and Europe for control of diseases caused by B. cineera, S. sclerotiorum, and Monilinia species in fruits, grapes, ornamental plants, turfgrass and vegetables. M1 and M2, are effective antagonists of the androgen receptor in rats exhibiting K_i values of 92 and 9.7 μM respectively. In fathead minnow, M1 and M2 failed to compete for high-affinity, low capacity testosterone binding sites in brain and ovary cytosolic fractions suggesting that they are not anti-androgens in this species.

参考文献

1 Pothuluri, J.V., Freeman, J.P., Heinze, T.M., et al. Biotransformation of vinclozolin by the fungus Cunninghemella elegans. J Agric Food Chem 48 6138-6148 (2000). 2 Kelce, W.R., Monosson, E., Gamcsik, M.P., et al. Enviromental hormone disruptors: Evid

Physical State :

Solid

Solubility :

Soluble in ethanol (~30 mg/ml), DMSO (~30 mg/ml), DMF (~30 mg/ml), and 1:1 ethanol:PBS (pH 7.2) (~0.5 mg/ml).

保存方法 :

Store at -20° C

Melting Point :

161.32° C (Predicted)

Boiling Point :

~426.9° C at 760 mmHg (Predicted)

Density :

~1.4 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.61 (Predicted)

Ki Data :

Androgen receptor: K_i= 9.7 µM (rat)

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

PubChem CID :

115209

MDL Number :

MFCD00871983

SMILES :

CC(C=C)(C(=O)NC1=CC(=CC(=C1)Cl)Cl)O

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Vinclozolin M2 (CAS 83792-61-4)

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参考文献

Download SDS (MSDS)

分析表

Vinclozolin M2 (CAS 83792-61-4)

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参考文献

Download SDS (MSDS)

分析表

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