TTDN1 Antibody (F-8): sc-393079

TTDN1 Antibody (F-8) is a mouse monoclonal IgG1 kappa light chain antibody that detects TTDN1 protein of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). anti-TTDN1 antibody (F-8) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. TTDN1, also known as C7orf11, ABHS, or ORF20, consists of 179 amino acids and is primarily localized in the nucleus, where TTDN1 plays a crucial role in maintaining cell cycle integrity, particularly in the regulation of mitosis and cytokinesis. This nuclear localization ensures proper cell division and function, which is essential for tissue growth and repair. TTDN1 is highly expressed in the kidney and liver, with lower expression levels found in the placenta, heart, skeletal muscle, pancreas, lung, and brain tissue. Mutations in the TTDN1 gene are linked to trichothiodystrophy non-photosensitive type 1, also known as Amish brittle hair brain syndrome, an autosomal recessive disorder characterized by decreased male fertility, short stature, and brittle hair. TTDN1 (F-8) antibody′s availability in various formats makes this product a versatile tool for researchers studying TTDN1′s role in cellular processes and related disorders.

Alexa Fluor^® is a trademark of Molecular Probes Inc., OR., USA

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TTDN1 Antibody (F-8) References:

1. Molecular genetic studies of human chromosome 7 in Russell-Silver syndrome.  |  Nakabayashi, K., et al. 2002. Genomics. 79: 186-96. PMID: 11829489
2. Identification of C7orf11 (TTDN1) gene mutations and genetic heterogeneity in nonphotosensitive trichothiodystrophy.  |  Nakabayashi, K., et al. 2005. Am J Hum Genet. 76: 510-6. PMID: 15645389
3. Trichothiodystrophy: report of a new case with severe nervous system impairment.  |  Rizzo, R., et al. 1992. J Child Neurol. 7: 300-3. PMID: 1634754
4. Mutations in the C7orf11 (TTDN1) gene in six nonphotosensitive trichothiodystrophy patients: no obvious genotype-phenotype relationships.  |  Botta, E., et al. 2007. Hum Mutat. 28: 92-6. PMID: 16977596
5. TTDN1 is a Plk1-interacting protein involved in maintenance of cell cycle integrity.  |  Zhang, Y., et al. 2007. Cell Mol Life Sci. 64: 632-40. PMID: 17310276
6. Mutations in the TTDN1 gene are associated with a distinct trichothiodystrophy phenotype.  |  Heller, ER., et al. 2015. J Invest Dermatol. 135: 734-741. PMID: 25290684
7. A homozygous G insertion in MPLKIP leads to TTDN1 with the hypergonadotropic hypogonadism symptom.  |  Zhou, YK., et al. 2018. BMC Med Genet. 19: 214. PMID: 30598092
8. A functional link between lariat debranching enzyme and the intron-binding complex is defective in non-photosensitive trichothiodystrophy.  |  Townley, BA., et al. 2023. Mol Cell. 83: 2258-2275.e11. PMID: 37369199
9. Activation of human RNA lariat debranching enzyme Dbr1 by binding protein TTDN1 occurs though an intrinsically disordered C-terminal domain.  |  Clark, NE., et al. 2023. J Biol Chem. 299: 105100. PMID: 37507019
10. Ribosomal Dysfunction Is a Common Pathomechanism in Different Forms of Trichothiodystrophy.  |  Zhu, G., et al. 2023. Cells. 12: PMID: 37508541
11. Trichothiodystrophy-associated MPLKIP maintains DBR1 levels for proper lariat debranching and ectodermal differentiation.  |  Theil, AF., et al. 2023. EMBO Mol Med. 15: e17973. PMID: 37800682
12. 'Brittle' hair with short stature, intellectual impairment and decreased fertility: an autosomal recessive syndrome in an Amish kindred.  |  Jackson, CE., et al. 1974. Pediatrics. 54: 201-7. PMID: 4847854

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-TTDN1 Antibody (F-8) has 1 citations in a variety of scientific publications.

Primary antibodies like Anti-TTDN1 Antibody (F-8) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

TTDN1 Antibody (F-8) Specifications

Alternate Product Name: TTDN1

Product Clone Name: F-8

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁ kappa light chain

Amino Acids: 1-179

Epitope Target: TTDN1

Epitope Species: human

Product Reactivity/Detection: TTDN1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG₁ kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 1 citations in various scientific publications

Available Conjugates/Forms for TTDN1 Antibody (F-8): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, PE: Phycoerythrin