p-Troponin I-C Antibody (5E6): sc-52274
- p-Troponin I-C Antibody (5E6) is a mouse monoclonal IgG2b p-Troponin I-C antibody provided at 100 µg/ml
- raised against phosphorylated form of human cardiac troponin I
- recommended for detection of a phosphorylated form of cardiac Troponin I of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for p-Troponin I-C Antibody (5E6). This work is in progress.
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p-Troponin I-C Antibody (5E6) is a mouse monoclonal IgG2b antibody that detects p-Troponin I-C protein of mouse, rat, and human origin by western blotting (WB) and immunoprecipitation (IP). anti-p-Troponin I-C antibody (5E6) is available as the non-conjugated format. p-Troponin I-C protein plays a critical role in cardiac muscle contraction by regulating the interaction between actin and myosin, which are essential for muscle contraction and movement. p-Troponin I-C is part of the troponin complex, which consists of three subunits: Troponin C, Troponin I, and Troponin T. Troponin C binds calcium ions, initiating a conformational change that allows myosin to interact with actin filaments, thereby facilitating muscle contraction. p-Troponin I-C is particularly important in cardiac health, as elevated levels in the bloodstream can serve as a biomarker for myocardial injury or stress. p-Troponin I-C antibody (5E6) enables valuable insights into cardiac function and underlying mechanisms of heart disease, making this reagent essential for both basic and clinical research applications.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
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p-Troponin I-C Antibody (5E6) References:
- Recombinant single chain cardiac troponin I-C polypeptides: superior calibration and control materials for cardiac troponin I immunoassays. | Liu, S., et al. 2001. Clin Lab. 47: 19-27. PMID: 11214219
- Measurement of circulating troponin Ic enhances the prognostic value of C-reactive protein in haemodialysis patients. | Boulier, A., et al. 2004. Nephrol Dial Transplant. 19: 2313-8. PMID: 15252159
- Sequential measurements of troponin Ic values in brain-dead patients considered as potential heart donors. | Boccheciampe, N., et al. 2007. Int J Cardiol. 117: 136-7. PMID: 17137648
- Effect of renal failure on peak troponin Ic level in patients with acute myocardial infarction. | Mekontso Dessap, A., et al. 2008. Cardiology. 109: 217-21. PMID: 17873484
- Serum troponin Ic values in organ donors are related to donor myocardial dysfunction but not to graft dysfunction or rejection in the recipients. | Boccheciampe, N., et al. 2009. Int J Cardiol. 133: 80-6. PMID: 18255177
- Quality of postoperative care after major orthopedic surgery is correlated with both long-term cardiovascular outcome and troponin Ic elevation. | Ausset, S., et al. 2010. Anesthesiology. 113: 529-40. PMID: 20733383
- Troponin I, C-reactive protein and fibrinogen levels in missed abortions. | Mollamahmutoğlu, L., et al. 2011. Clin Exp Obstet Gynecol. 38: 60-2. PMID: 21485729
- Conformation and Dynamics of the Troponin I C-Terminal Domain: Combining Single-Molecule and Computational Approaches for a Disordered Protein Region. | Metskas, LA. and Rhoades, E. 2015. J Am Chem Soc. 137: 11962-9. PMID: 26327565
- Heart Failure-Related Hyperphosphorylation in the Cardiac Troponin I C Terminus Has Divergent Effects on Cardiac Function In Vivo. | Li, Y., et al. 2017. Circ Heart Fail. 10: PMID: 28899987
- Establishment and Application of a Dual-Labeling Time-Resolved Fluorescence Immunoassay Method for Simultaneous Detection of the Troponin I-C Complex and Full-Size-Troponin I. | Huang, B., et al. 2020. Front Cardiovasc Med. 7: 596051. PMID: 33521060
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
p-Troponin I-C Antibody (5E6) | sc-52274 | 100 µg/ml | $322.00 |