TRAF2 Antibody (G-3): sc-136998
- TRAF2 Antibody (G-3) is a mouse monoclonal IgG2b κ provided at 200 µg/ml
- raised against amino acids 1-249 of TRAF2 of human origin
- recommended for detection of TRAF2 of mouse, rat and human origin by WB, IP, IF and ELISA
- See TRAF2 (F-2): sc-136999 for TRAF2 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for TRAF2 Antibody (G-3) for WB applications. These reagents are now offered in bundles with TRAF2 Antibody (G-3) (see ordering information below).
TRAF2 Antibody (G-3) is a mouse monoclonal IgG2b antibody that detects TRAF2 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). TRAF2 plays a crucial role in mediating tumor necrosis factor (TNF) receptor signaling, particularly through interaction with TNF receptor 1 (TNF-R1) and TNF receptor 2 (TNF-R2), which are integral to the regulation of immune responses and inflammation. TRAF2 is primarily located in the cytoplasm, where TRAF2 forms heterodimeric complexes with TRAF1 and other signaling molecules, facilitating the transmission of signals that lead to cell survival, proliferation, and apoptosis. Understanding the localization and function of TRAF2 is vital, as dysregulation can contribute to various diseases, including autoimmune disorders and cancer. anti-TRAF2 antibody (G-3) is an essential tool for researchers aiming to explore the complexities of TNF receptor signaling pathways and their implications in health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
TRAF2 Antibody (G-3) References:
- TRAF2 multitasking in TNF receptor-induced signaling to NF-κB, MAP kinases and cell death. | Borghi, A., et al. 2016. Biochem Pharmacol. 116: 1-10. PMID: 26993379
- cIAP1/TRAF2 interplay promotes tumor growth through the activation of STAT3. | Dumétier, B., et al. 2023. Oncogene. 42: 198-208. PMID: 36400972
- The deubiquitinating enzyme OTUD7b protects dendritic cells from TNF-induced apoptosis by stabilizing the E3 ligase TRAF2. | Harit, K., et al. 2023. Cell Death Dis. 14: 480. PMID: 37516734
- TRAF2/3 deficient B cells resist DNA damage-induced apoptosis via NF-κB2/XIAP/cIAP2 axis and IAP antagonist sensitizes mutant lymphomas to chemotherapeutic drugs. | Vashisht, M., et al. 2023. Cell Death Dis. 14: 599. PMID: 37679334
- The natural compound Sanggenon C inhibits PRRSV infection by regulating the TRAF2/NF-κB signalling pathway. | Liu, X., et al. 2023. Vet Res. 54: 114. PMID: 38037100
- Silencing of CPNE1-TRAF2 Axis Restrains the Development of Pancreatic Cancer. | Song, Y., et al. 2023. Front Biosci (Landmark Ed). 28: 316. PMID: 38062811
- The Traf2 and NcK interacting kinase inhibitor NCB-0846 suppresses seizure activity involving the decrease of GRIA1. | Wang, M., et al. 2024. Genes Dis. 11: 100997. PMID: 38292191
- CRISPR-Cas9 screen of E3 ubiquitin ligases identifies TRAF2 and UHRF1 as regulators of HIV latency in primary human T cells. | Rathore, U., et al. 2024. mBio. 15: e0222223. PMID: 38411080
- B(a)P induces ovarian granulosa cell apoptosis via TRAF2-NFκB-Caspase1 axis during early pregnancy. | Xu, H., et al. 2024. Environ Res. 252: 118865. PMID: 38583661
- USP24 promotes hepatocellular carcinoma tumorigenesis through deubiquitinating and stabilizing TRAF2. | Zhou, N., et al. 2024. Biochem Pharmacol. 229: 116473. PMID: 39127151
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
TRAF2 Antibody (G-3) | sc-136998 | 200 µg/ml | $322.00 | |||
TRAF2 Antibody (G-3): m-IgG Fc BP-HRP Bundle | sc-537385 | 200 µg Ab; 10 µg BP | $361.00 | |||
TRAF2 Antibody (G-3): m-IgGκ BP-HRP Bundle | sc-534636 | 200 µg Ab; 40 µg BP | $361.00 |