Tachykinin Antibody (H-2): sc-25266
- Tachykinin Antibody (H-2) is a mouse monoclonal IgG2a κ provided at 200 µg/ml
- raised against amino acids 1-129 of Tachykinin of human origin
- Anti-Tachykinin Antibody (H-2) is recommended for detection of Tachykinin of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-Tachykinin Antibody (H-2) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP and m-IgG2a BP-HRP are the preferred secondary detection reagents for Tachykinin Antibody (H-2) for WB and IHC(P) applications. These reagents are now offered in bundles with Tachykinin Antibody (H-2) (see ordering information below).
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Tachykinin Antibody (H-2) is a mouse monoclonal IgG2a kappa light chain antibody that targets Tachykinin, a family of neuropeptides that includes Substance P, Neurokinin A (also known as Substance K or Neuromedin L), and Neurokinin B. Tachykinins are synthesized as preprotachykinin I (PPT I) and are predominantly located in neuronal cells within both the central and peripheral nervous systems, where they play crucial roles in neurotransmission, modulation of pain perception, inflammation, and vasodilation. Anti-Tachykinin antibody (H-2) is raised against amino acids 1-129 of human Tachykinin, targeting Tachykinins of mouse, rat, and human origin in applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). Detecting Tachykinin′s cellular localization is important because its presence in neurons affects neuronal communication and responses to physiological stimuli, impacting research in neuroscience and immunology. Tachykinin monoclonal antibody (H-2) is available in both non-conjugated form and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates, offering versatility for different experimental needs. Understanding the distribution and function of Tachykinins aids in studying conditions like pain, depression, and cancer metastasis, making Tachykinin (H-2) antibody a valuable tool for biomedical research.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Tachykinin Antibody (H-2) References:
- Increased expression of preprotachykinin-I and neurokinin receptors in human breast cancer cells: implications for bone marrow metastasis. | Singh, D., et al. 2000. Proc Natl Acad Sci U S A. 97: 388-93. PMID: 10618428
- Excessive placental secretion of neurokinin B during the third trimester causes pre-eclampsia. | Page, NM., et al. 2000. Nature. 405: 797-800. PMID: 10866201
- Neuroanatomical localisation of Substance P in the CNS and sensory neurons. | Ribeiro-da-Silva, A. and Hökfelt, T. 2000. Neuropeptides. 34: 256-71. PMID: 11049730
- Cloning of human preprotachykinin-I promoter and the role of cyclic adenosine 5'-monophosphate response elements in its expression by IL-1 and stem cell factor. | Qian, J., et al. 2001. J Immunol. 166: 2553-61. PMID: 11160316
- Characterization of the C-terminal flanking peptide of human beta-preprotachykinin. | McGregor, GP. and Conlon, JM. 1990. Peptides. 11: 907-10. PMID: 2284201
- Distinct mechanism for antidepressant activity by blockade of central substance P receptors. | Kramer, MS., et al. 1998. Science. 281: 1640-5. PMID: 9733503
- Identification of a delta isoform of preprotachykinin mRNA in human mononuclear phagocytes and lymphocytes. | Lai, JP., et al. 1998. J Neuroimmunol. 91: 121-8. PMID: 9846828
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Tachykinin Antibody (H-2) | sc-25266 | 200 µg/ml | $322.00 | |||
Tachykinin Antibody (H-2): m-IgG Fc BP-HRP Bundle | sc-525514 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tachykinin Antibody (H-2): m-IgG2a BP-HRP Bundle | sc-546298 | 200 µg Ab; 10 µg BP | $361.00 | |||
Tachykinin Antibody (H-2) AC | sc-25266 AC | 500 µg/ml, 25% agarose | $424.00 | |||
Tachykinin Antibody (H-2) HRP | sc-25266 HRP | 200 µg/ml | $322.00 | |||
Tachykinin Antibody (H-2) FITC | sc-25266 FITC | 200 µg/ml | $336.00 | |||
Tachykinin Antibody (H-2) PE | sc-25266 PE | 200 µg/ml | $349.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 488 | sc-25266 AF488 | 200 µg/ml | $364.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 546 | sc-25266 AF546 | 200 µg/ml | $364.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 594 | sc-25266 AF594 | 200 µg/ml | $364.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 647 | sc-25266 AF647 | 200 µg/ml | $364.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 680 | sc-25266 AF680 | 200 µg/ml | $364.00 | |||
Tachykinin Antibody (H-2) Alexa Fluor® 790 | sc-25266 AF790 | 200 µg/ml | $364.00 |