Molecular structure of Sulfasalazine, CAS Number: 599-79-1
Sulfasalazine (CAS 599-79-1)
See product citations (8)
Alternate Names:
5-[4-(2-Pyridylsulfamoyl)phenylazo]salicylic acid
Application:
Sulfasalazine is an inhibitor of of GSH-H-transferase and NF-kB activation and an apoptosis inducer
CAS Number:
599-79-1
Purity:
≥95%
Molecular Weight:
398.39
Molecular Formula:
C18H14N4O5S
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Sulfasalazine is an antiinflammatory agent that inhibits GSH-H-transferase. Sulfasalazine largely inhibits NF-kappaB activation and induces apoptosis in T-lymphocytes. The compound also engages neutrophil apoptosis that can be abrogated by Tyr-K inhibitors, PKA inhibitors, or antioxidants. Sulfasalazine is shown to inhibit basic fibroblast growth factor-induced endothelial cell chemotaxis. Sulfasalazine is an inhibitor of TNFα and an activator of PPARγ.
Sulfasalazine (CAS 599-79-1) References
- Sulfasalazine associated agranulocytosis in Sweden 1972-1989. Clinical features, and estimation of its incidence. | Keisu, M. and Ekman, E. 1992. Eur J Clin Pharmacol. 43: 215-8. PMID: 1358622
- Toxicity of sulfasalazine in systemic juvenile chronic arthritis. | Hertzberger-ten Cate, R. and Cats, A. 1991. Clin Exp Rheumatol. 9: 85-8. PMID: 1675939
- Immunochemical method for sulfasalazine determination in human plasma. | Pastor-Navarro, N., et al. 2007. Anal Chim Acta. 583: 377-83. PMID: 17386570
- Evolution of olsalazine. | Truelove, SC. 1988. Scand J Gastroenterol Suppl. 148: 3-6. PMID: 2906475
- A solid-phase luminescence sensor based on molecularly imprinted polymer-CdSeS/ZnS quantum dots for selective extraction and detection of sulfasalazine in biological samples. | Ahmadpour, H. and Hosseini, SMM. 2019. Talanta. 194: 534-541. PMID: 30609569
- The association between NAT2 acetylator status and adverse drug reactions of sulfasalazine: a systematic review and meta-analysis. | Yee, J., et al. 2020. Sci Rep. 10: 3658. PMID: 32107440
- Fibrosing alveolitis and treatment with sulphasalazine. | Davies, D. and MacFarlane, A. 1974. Gut. 15: 185-8. PMID: 4152289
- Pharmacotherapy of inflammatory bowel disease. Part 1. Sulfasalazine. | Das, KM. 1983. Postgrad Med. 74: 141-8, 150-1. PMID: 6139795
- Sulphasalazine: a 'new' antirheumatic drug. | Pullar, T. and Capell, HA. 1984. Br J Rheumatol. 23: 26-34. PMID: 6141832
- Sulphasalazine in rheumatic diseases. | Dougados, M. 1993. Agents Actions Suppl. 44: 197-201. PMID: 8103962
- Sulphasalazine, sulphapyridine or 5-aminosalicylic acid--which is the active moiety in rheumatoid arthritis? | Bird, HA. 1995. Br J Rheumatol. 34 Suppl 2: 16-9. PMID: 8535642
- The antirheumatic agents sulphasalazine and methotrexate share an anti-inflammatory mechanism. | Cronstein, BN. 1995. Br J Rheumatol. 34 Suppl 2: 30-2. PMID: 8535646
- Sulphasalazine: mechanism of action in rheumatoid arthritis. | Smedegård, G. and Björk, J. 1995. Br J Rheumatol. 34 Suppl 2: 7-15. PMID: 8535652
Inhibitor of:
α-defensin 1B, β-defensin 1, β-defensin 116, β-defensin 125, β-defensin 47, βA3/A1-crystallin, γ-FR, γ-GCSm, 4732471D19Rik, A1BG, Aasdh, ABCC12, AMAC1L1, ANG V, ANK-1, ATHL1, AUH, BAI-1, BCRF1, C1QTNF (C1q and TNF related), C20orf54, calsyntenin-1, CARD 6, CARD 9, CD16, CD21L, CD62L ligand, CILP, CNOX, cornulin, CRSP34_Med27, cryptdin 13, cryptdin 15, CTRP4, DDO, DNAM-1, DPEP2, DUX, ECHDC1, ELFN1, FARP2, FRP-1, GI24, glutathione S-transferase mu (GSTM), Glyoxalase I, GPx-2, GRAIL, Granulocyte Marker, Granulocytee Marker, GSH-1, Gsta1, GSTM3, GSTM4, GSTM5, GSTO2, GSTT2B, HCP1 (SLC46A1), HIV vpr, HLA-B27, HNP, HoxC10, IκB-γ, IEX-1, IFIT1L, IFN-α9, IFRD2, Igbp1b, IgG λ light chain, IgG3, IL-1ε F6, IL-10, IL-12A p35, IL-13, IL-17C, IL-5R, IL-7R, ILT-11, KRTAP16-7, LACC1, LIR-7, LOC100039855, LOC622307, Ly-49G, Ly-49W, Ly6G6e, MFT, MGST2, MIG, MSR, MTRR, Multimerin-2, MYEF2, NF kappa B, NF-1B, NF-1X, NFKBIL2, NFRκB, OAT2, OATP-E, Olfr630, OPN, OTTMUSG00000015050, PADI1, PEBP2β, peroxidase, PGDH, PGLS, PLAA, PLZF, PPARα, PRPSAP1, Rae-1δ, RFC-1, Rheumatoid Factor, RORα, rotavirus vp7, RT1-Ac, SAA4, SGS3, SIMC1, Skint1, Skint5, Skint6, Skint8, SLC22A12, SPG3A, SPRR4, T-cell receptor Vδ 1, T-cell receptor Vδ 2, TANK, TCR α, Tenr, Thioguanine, THP, TMCC2, TNF alpha, TNF-IP 1, TNFα-IP 8, TNIP2 (Abin-2), TPMT, TRAFD1, Trav12n-1, TRIM30A, TrxR1, TWEAK, USP10, xCT, ZAG, and ZNF263.Activator of:
α3e Tubulin, 2610305D13Rik, A230051G13Rik, Abcg3, CCL23, CD137L, CR1L, CRIP1, EAAT4, eIF2Bγ, Folate, GGH, GGT6, GMPS, GPATCH3, GPx-4, GSTM7, GSTO1, HAPLN4, HSGT1, IκB-β, IκB-γ, IKIP, IL-17RA, IL-1F9, IL-1RII, IL-21R, IL-22Rα2, IL-32, LOC100039946, LOC100041296, Lumican, LYRM4, MAdCAM-1, MCP-3, Mel13, Miner2, Mitochondrial CysRs, MMD, mMGL, NALP4B, NKRF, Oatp-Y, PPAR gamma, RFX4, RNF183, RP105, SerpinB11, SP-D, TNFα-IP 1, TNFα-IP 8L3, TPN, TROY, and ZnT-5.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Sulfasalazine, 1 g | sc-204312 | 1 g | $61.00 | |||
Sulfasalazine, 2.5 g | sc-204312A | 2.5 g | $77.00 | |||
Sulfasalazine, 5 g | sc-204312B | 5 g | $128.00 | |||
Sulfasalazine, 10 g | sc-204312C | 10 g | $209.00 |