Septin 5 Antibody (H-9): sc-390529

Septin 5 Antibody (H-9) is a mouse monoclonal IgM antibody that detects Septin 5 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Septin 5 plays a crucial role in the organization of the cytoskeleton and is involved in various cellular processes, including cytokinesis and the regulation of exocytosis. Septin 5 is primarily localized in the cytoplasm and is essential for maintaining the structural integrity of the cell during division, which is vital for proper tissue development and function. Additionally, Septin 5 has been implicated in the formation of septin heteropolymers, which are important for cellular compartmentalization and signaling. Septin 5′s ability to interact with other proteins, such as those involved in the TGF-β signaling pathway, highlights its significance in apoptosis and cell cycle regulation. The complex transcriptional regulation of septins, including alternative splicing, further emphasizes the diverse functional roles that Septin 5 may play in different cellular contexts. With critical involvement in fundamental cellular processes, Septin 5 is a key protein for researchers studying cell biology, cancer, and neurodegenerative diseases.

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Septin 5 Antibody (H-9) References:

1. Expression profiles of proteins in fetal brain with Down syndrome.  |  Cheon, MS., et al. 2001. J Neural Transm Suppl. 311-9. PMID: 11771754
2. Calpain inhibition stabilizes the platelet proteome and reactivity in diabetes.  |  Randriamboavonjy, V., et al. 2012. Blood. 120: 415-23. PMID: 22665935
3. Quantification of the brain proteome in Alzheimer's disease using multiplexed mass spectrometry.  |  Musunuri, S., et al. 2014. J Proteome Res. 13: 2056-68. PMID: 24606058
4. Differential expression of synaptic proteins in unilateral 6-OHDA lesioned rat model-A comparative proteomics approach.  |  Xiong, Y., et al. 2014. Proteomics. 14: 1808-19. PMID: 24841483
5. Brain γ-Tocopherol Levels Are Associated with Presynaptic Protein Levels in Elderly Human Midfrontal Cortex.  |  de Leeuw, FA., et al. 2020. J Alzheimers Dis. 77: 619-627. PMID: 32741813
6. Expanded Clinical Phenotype, Oncological Associations, and Immunopathologic Insights of Paraneoplastic Kelch-like Protein-11 Encephalitis.  |  Dubey, D., et al. 2020. JAMA Neurol. 77: 1420-1429. PMID: 32744608
7. Identification of Caveolae-Associated Protein 4 Autoantibodies as a Biomarker of Immune-Mediated Rippling Muscle Disease in Adults.  |  Dubey, D., et al. 2022. JAMA Neurol. 79: 808-816. PMID: 35696196
8. SARS-CoV-2 antibodies in inflammatory neurological conditions: a multicentre retrospective comparative study.  |  Zivelonghi, C., et al. 2023. Immunol Res. 71: 717-724. PMID: 37171542
9. Clinical features and outcomes in primary nervous system histiocytic neoplasms.  |  Nathoo, N., et al. 2024. Blood Cancer J. 14: 101. PMID: 38902249
10. Innovation and optimization in autoimmune encephalitis trials: the design and rationale for the Phase 3, randomized study of satralizumab in patients with NMDAR-IgG-antibody-positive or LGI1-IgG-antibody-positive autoimmune encephalitis (CIELO).  |  Lee, ST., et al. 2024. Front Neurol. 15: 1437913. PMID: 39193150

The preferred Septin 5 antibody is Septin 5 Antibody (SP18): sc-20040.