Rosuvastatin Calcium Salt (CAS 147098-20-2)

外観 :

Powder

身体の状態 :

Solid

溶解度 :

Soluble in water (< 1 mg/ml at 25° C), chloroform, DMSO (100 mg/ml at 25° C), methanol, and ethanol (< 1 mg/ml at 25° C).

保存方法 :

Store at -20° C

融点 :

151-156° C

屈折率 :

n²⁰_D 1.60 (Predicted)

光学活性 :

α20/D +6.8°, c = 1 in methanol; α20/D -9.9°, c = 1 in chloroform; α20/D +14.8°, c = 1.012 in 50% MeOH

IC50 :

HMG-CoA reductase: IC₅₀ = 2.1 nM (rat); HMGCRHMGCRHMGCR: IC₅₀ = 3.1 nM (human); Liver microsomes: IC₅₀ = 3.6 nM (rat); L6: IC₅₀ = 65 nM (rat); Plasmodium falciparum: IC₅₀ = 80 µM

Ki データ :

HMGCRHMGCRHMGCR: K_i= 0.9 (human)

RTECS :

MJ9675070

PubChem CID :

MDL番号 :

MFCD04112702

SMILES :

CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.CC(C1=NC(=NC(=C1/C=C/[C@H](O)C[C@@H](O)CC(=O)[O-])C2=CC=C(C=C2)F)N(S(=O)(=O)C)C)C.[Ca+2]