Relaxin Receptor 1 Antibody (3E3): sc-293228

Relaxin Receptor 1 Antibody (3E3) is a mouse monoclonal IgG2a kappa light chain antibody that detects Relaxin Receptor 1 protein of human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Anti-Relaxin Receptor 1 antibody (3E3) is available as a non-conjugated format. Relaxin Receptor 1, also known as Relaxin/insulin-like family peptide receptor 1, RXFP1, LGR7, or RXFPR1, is a crucial member of the G protein-coupled receptor family, which plays a significant role in mediating various physiological processes. Relaxin Receptor 1 is primarily located in the cell membrane and is characterized by ten leucine-rich repeats and an LDL-receptor class A domain, which are essential for ligand binding and receptor activation. Upon binding of Relaxin or insulin-like peptide 3 (INSL3), Relaxin Receptor 1 activates adenylate cyclase, resulting in an increase in intracellular cyclic adenosine monophosphate (cAMP) levels. cAMP serves as a vital second messenger that regulates numerous hormonal activities, including those of adrenocorticotropic hormone, glucagon, and epinephrine, thereby influencing various cellular functions. Expression of Relaxin Receptor 1 in diverse tissues such as brain, placenta, uterus, kidney, prostate, testis, adrenal glands, heart, ovary, and skin underscores its importance in reproductive and cardiovascular physiology. Alternative splicing of Relaxin Receptor 1 gene leads to production of two distinct isoforms, further diversifying functional roles in human biology.

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Relaxin Receptor 1 Antibody (3E3) References:

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