PYGB/M Antibody (3G1): sc-51925

PYGB/M Antibody (3G1) is a mouse monoclonal IgG1 antibody that detects the PYGB/M protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-PYGB/M antibody (3G1) is available as a non-conjugated format. PYGB/M protein, also known as glycogen phosphorylase, plays a crucial role in carbohydrate metabolism by catalyzing the breakdown of glycogen into glucose-1-phosphate, which is essential for energy production in cells. Glycogen phosphorylase is particularly important in tissues that require rapid energy mobilization, such as muscle and liver, where various allosteric effectors and covalent modifications regulate PYGB/M activity. Glycogen phosphorylase activity is tightly controlled to ensure glucose release into the bloodstream when energy demands are high, making PYGB/M a key player in maintaining glucose homeostasis. Dysregulation of glycogen phosphorylase can lead to metabolic disorders, including type 2 diabetes mellitus, highlighting PYGB/M′s significance as a therapeutic target. PYGB/M monoclonal antibody (3G1) serves as an invaluable tool for researchers studying glycogen metabolism and its implications in metabolic diseases.

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PYGB/M Antibody (3G1) References:

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5. Novel variant in the PYGM gene causing late-onset limb-girdle myopathy, ptosis, and camptocormia.  |  Chéraud, C., et al. 2018. Muscle Nerve. 57: 157-160. PMID: 28120463
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7. Breast cancers utilize hypoxic glycogen stores via PYGB, the brain isoform of glycogen phosphorylase, to promote metastatic phenotypes.  |  Altemus, MA., et al. 2019. PLoS One. 14: e0220973. PMID: 31536495
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