PRELI Antibody (QF-7): sc-100817
- PRELI Antibody (QF-7) is a mouse monoclonal IgG1 κ, cited in 1 publications, provided at 100 µg/ml
- raised against recombinant PRELI of human origin
- recommended for detection of PRELI of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PRELI Antibody (QF-7). This work is in progress.
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PRELI Antibody (QF-7) is a mouse monoclonal IgG1 antibody that detects PRELI in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). PRELI, also known as PRELID1, is a 219 amino acid mitochondrial protein encoded within a conserved gene cluster that includes IκB-α and Rab 24. PRELI plays a crucial role in the development of immunocompetent organs, as PRELI is highly expressed in fetal liver, a primary site for B cell lymphopoiesis, and PRELI expression significantly decreases during maturation, shifting to predominant levels in the brain, lymph nodes, peripheral blood leukocytes, and spleen. The expression pattern of PRELI suggests PRELI′s importance in immune system development and function. Notably, PRELI contains a late embryogenesis abundant (LEA) motif, which is typically associated with plant proteins, indicating a potential evolutionary link between plants and animals. Additionally, the N-terminal region of PRELI features a 170 amino acid PRELI/MSF1 domain, which may be involved in interactions with cellular membranes, further underscoring PRELI′s significance in cellular processes. With diverse applications and critical role in immunology, anti-PRELI antibody (QF-7) is an essential tool for researchers studying immune system development and function.
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PRELI Antibody (QF-7) References:
- PRELI, the human homologue of the avian px19, is expressed by germinal center B lymphocytes. | Guzman-Rojas, L., et al. 2000. Int Immunol. 12: 607-12. PMID: 10784606
- PRELI (protein of relevant evolutionary and lymphoid interest) is located within an evolutionarily conserved gene cluster on chromosome 5q34-q35 and encodes a novel mitochondrial protein. | Fox, EJ., et al. 2004. Biochem J. 378: 817-25. PMID: 14640972
- PRELI is a mitochondrial regulator of human primary T-helper cell apoptosis, STAT6, and Th2-cell differentiation. | Tahvanainen, J., et al. 2009. Blood. 113: 1268-77. PMID: 18945965
- TRIAP1/PRELI complexes prevent apoptosis by mediating intramitochondrial transport of phosphatidic acid. | Potting, C., et al. 2013. Cell Metab. 18: 287-95. PMID: 23931759
- Mitochondrial lipid trafficking. | Tatsuta, T., et al. 2014. Trends Cell Biol. 24: 44-52. PMID: 24001776
- Structural insight into the TRIAP1/PRELI-like domain family of mitochondrial phospholipid transfer complexes. | Miliara, X., et al. 2015. EMBO Rep. 16: 824-35. PMID: 26071602
- Effects of PRELI in Oxidative-Stressed HepG2 Cells. | Kim, BY., et al. 2015. Ann Clin Lab Sci. 45: 419-25. PMID: 26275693
- Structural determinants of lipid specificity within Ups/PRELI lipid transfer proteins. | Miliara, X., et al. 2019. Nat Commun. 10: 1130. PMID: 30850607
- Lipid metabolism-related proteins of relevant evolutionary and lymphoid interest (PRELI) domain containing family proteins in cancer. | Zhu, Y., et al. 2020. Am J Transl Res. 12: 6015-6026. PMID: 33194011
- MicroRNA Profiling of PRELI-Modulated Exosomes and Effects on Hepatic Cancer Stem Cells. | Kim, B. 2024. Int J Mol Sci. 25: PMID: 39769068
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PRELI Antibody (QF-7) | sc-100817 | 100 µg/ml | $339.00 |