PP5 Antibody (3): sc-136046
- PP5 Antibody (3) is a mouse monoclonal IgG1, cited in 1 publications, provided at 50 µg/0.5 ml
- raised against amino acids 36-238 of PP5 of rat origin
- recommended for detection of PP5 of mouse, rat, human and canine origin by WB, IP and IF
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for PP5 Antibody (3). This work is in progress.
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PP5 Antibody (3) is a mouse monoclonal IgG1 antibody that detects PP5 in mouse, rat, human, and canine samples through western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF) applications. PP5, also known as Protein phosphatase T (PP-T, PPP5C), plays a crucial role in cellular regulation by dephosphorylating serine residues on various substrates, including skeletal muscle phosphorylase and histone H1, which are vital for processes such as mitosis and RNA biogenesis. PP5 maintains predominantly nuclear localization, where anti-PP5 antibody (3) can detect interactions with key proteins like CDC16 and CDC27, thereby influencing cell cycle progression and gene expression. PP5′s ability to modulate phosphorylation states is essential for maintaining cellular homeostasis and ensuring proper cellular responses to external signals. PP5 monoclonal antibody (3) serves as an invaluable tool for researchers studying the intricate mechanisms of protein regulation and signaling pathways in various biological contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
PP5 Antibody (3) References:
- Identification of an estrogen-inducible phosphatase (PP5) that converts MCF-7 human breast carcinoma cells into an estrogen-independent phenotype when expressed constitutively. | Urban, G., et al. 2001. J Biol Chem. 276: 27638-46. PMID: 11331294
- Elevated levels of Ser/Thr protein phosphatase 5 (PP5) in human breast cancer. | Golden, T., et al. 2008. Biochim Biophys Acta. 1782: 259-70. PMID: 18280813
- The therapeutic target Hsp90 and cancer hallmarks. | Miyata, Y., et al. 2013. Curr Pharm Des. 19: 347-65. PMID: 22920906
- Steroid Receptor-Associated Immunophilins: A Gateway to Steroid Signalling. | Ratajczak, T., et al. 2015. Clin Biochem Rev. 36: 31-52. PMID: 26224894
- Structure and function of the co-chaperone protein phosphatase 5 in cancer. | Sager, RA., et al. 2020. Cell Stress Chaperones. 25: 383-394. PMID: 32239474
- Over-expression of human PP5 gene in mice induces corneal hyperplasia and leads to ocular surface squamous neoplasia. | Dou, L., et al. 2020. Biochem Biophys Res Commun. 529: 487-493. PMID: 32703456
- GTP Signaling Links Metabolism, DNA Repair, and Responses to Genotoxic Stress. | Zhou, W., et al. 2024. Cancer Discov. 14: 158-175. PMID: 37902550
- The phosphatase inhibitor LB-100 creates neoantigens in colon cancer cells through perturbation of mRNA splicing. | Dias, MH., et al. 2024. EMBO Rep. 25: 2220-2238. PMID: 38600345
- Regulation of RAF family kinases: new insights from recent structural and biochemical studies. | Spencer-Smith, R. and Morrison, DK. 2024. Biochem Soc Trans. 52: 1061-1069. PMID: 38695730
- SUMOylation of protein phosphatase 5 regulates phosphatase activity and substrate release. | Sager, RA., et al. 2024. EMBO Rep. 25: 4636-4654. PMID: 39304777
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PP5 Antibody (3) | sc-136046 | 50 µg/0.5 ml | $322.00 |