PNU 112455A hydrochloride CAS: 21886-12-4
MF: C10H11N5O2S•HCl
MW: 301.76
An ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25.

PNU 112455A hydrochloride (CAS 21886-12-4)

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getAggregateRating, 98ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
別名: Cdk2/5 Inhibitor
アプリケーション: PNU 112455A hydrochloride is an ATP-competitive inhibitor of CDK2/cyclin E and CDK5/p25
CAS 番号: 21886-12-4
Purity: ≥95%
Molecular Weight: 301.76
Molecular Formula: C10H11N5O2S•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data (including water content).

PNU 112455A hydrochloride is a selective and ATP-competitive inhibitor of CDK2/cyclin E (Ki = 2 μM) and CDK5/p35 (p25) (Ki = 2 μM). It binds to the ATP-binding pocket of CDK2 and does not affect the activities of c-met, IGF-1 receptor tyrosine kinase, cAMP-dependent kinase and ERK2 at concentrations as high as 100 μM.


参考文献

P.M. Clare, et al.; J. Biol. Chem. 276, 48292 (2001).

Physical State :
Solid
Solubility :
Soluble in DMSO (5 mg/ml,clear solution), and water.
保存方法 :
Store at -20° C
Melting Point :
293-295° C
Boiling Point :
578.9° C at 760 mmHg (Predicted)
Refractive Index :
n20D 1.70 (Predicted)
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
WGK Germany :
3
PubChem CID :
MDL Number :
MFCD00023272
SMILES :
C1=CC(=CC=C1NC2=NC=NC(=C2)N)S(=O)(=O)N.Cl

Download SDS (MSDS)

分析表

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getContent, 85ms
  • QUESTIONS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;
  • bvseo_sdk, java_sdk, bvseo-3.2.0
  • CLOUD, getReviews, 6ms
  • REVIEWS, PRODUCT
  • bvseo-msg: The resource to the URL or file is currently unavailable.;

サンタクルーズバイオテクノロジーは生物医学研究市場向けの製品の開発における世界的リーダです。 下記フリー ダイヤルにお電話ください: 1-800-457-3801。Copyright © 2007-2021 Santa Cruz Biotechnology, Inc.全著作権所有。"Santa Cruz Biotechnology"、 及びSanta Cruz Biotechnology, Inc. ロゴ、 "Santa Cruz Animal Health"、 "San Juan Ranch"、 "Supplement of Champions"、 San Juan Ranch ロゴ、 "Ultracruz"、 "Chemcruz"、 "Immunocruz"、 "Exactacruz"、 と "EZ Touch"はサンタクルーズバイオテクノロジーの登録商標です。 商標はそれぞれの所有者に帰属します。