Phocein Antibody (E-6): sc-165980

Phocein Antibody (E-6) is a mouse monoclonal IgG2b antibody that detects Phocein in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Phocein, a 225 amino acid protein encoded by the human gene MOBKL3, plays a crucial role in cellular signaling and trafficking, primarily due to interactions with the striatin family of scaffolding proteins. These interactions are vital for the organization of signaling complexes and regulation of endocytic processes, which are essential for maintaining cellular homeostasis and communication. Phocein is predominantly associated with membranes but can also be found in the cytosol, where protein complexes form to facilitate vesicular trafficking. Phosphorylation on serine residues and the presence of a putative SH3-binding domain further enhance functional versatility, allowing engagement with various partners, including Dynamin and nucleotide diphosphate kinase, thereby influencing the dynamics of vesicle formation and transport. Anti-Phocein antibody (E-6) serves as an invaluable tool for researchers investigating the intricate mechanisms of cellular transport and signaling pathways.

The preferred Phocein antibody is Phocein Antibody (D-5): sc-137229.