Perphenazine (CAS 58-39-9)

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アプリケーション： Perphenazine is a D2DR inhibitor

CAS 番号: 58-39-9

Purity: ≥99%

Molecular Weight: 403.97

Molecular Formula: C₂₁H₂₆ClN₃OS

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* Refer to Certificate of Analysis for lot specific data (including water content).

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Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells.

参考文献

1. Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62(6): 419-425. PMID: 16583980

2. Yuan, L.B. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30(3): 288-291. PMID: 16045015

Physical State :

Solid

Solubility :

Soluble in ethanol (50 mg/ml), water (0.028 mg/ml at 24° C), methanol, and chloroform.

保存方法 :

Store at 4° C

Melting Point :

97° C (lit.)

Boiling Point :

580.4° C at 760 mmHg

Density :

~1.3 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.63 (Predicted)

IC50 :

AOX1: IC₅₀ = 33 nM (human); Aldehyde oxidase: IC₅₀ = 740 nM (rat); Pleiotropic ABC efflux transporter of multiple drugs: IC₅₀ = 1.4 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC₅₀ = 2.51 µM; HERG: IC₅₀ = 4.22 µM (human)

Ki Data :

SR-7: K_i= 23 nM (human); HERG: K_i= 3.45 µM (human)

pK Values :

pK_a: 7.39, pK_b: 7.94 (Predicted)

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

WGK Germany :

3

PubChem CID :

4748

Merck Index :

14: 7183

MDL Number :

MFCD00056798

EC Number :

200-381-5

SMILES :

C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

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Perphenazine (CAS 58-39-9)

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参考文献

Download SDS (MSDS)

分析表

Perphenazine (CAS 58-39-9)

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参考文献

Download SDS (MSDS)

分析表

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