Perphenazine CAS: 58-39-9
MF: C21H26ClN3OS
MW: 403.97
Perphenazine is a D2DR inhibitor.

Perphenazine (CAS 58-39-9)

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アプリケーション: Perphenazine is a D2DR inhibitor
CAS 番号: 58-39-9
Purity: ≥99%
Molecular Weight: 403.97
Molecular Formula: C21H26ClN3OS
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* Refer to Certificate of Analysis for lot specific data (including water content).

Perphenazine is a D2DR inhibitor which inhibits the glutamate dehydrogenase in vitro. Perphenazine also acts as a α-adrenergic receptor antagonist and σ-receptor agonist. Studies indicate that uncharged Perphenazine is better at forming complexes with cyclodextrins. In addition, Perphenazine forms more stable complexes with cyclodextrins than fluphenazine (sc-205700). Studies show that Perphenazine enhances the expression of CD71 on K562 cells, while at the same time inhibiting the proliferation of these cells.


参考文献

1. Lutka, A. and Prange, W. 2005. Acta Pol Pharm. 62(6): 419-425. PMID: 16583980

2. Yuan, L.B. and He, Q. 2005. Zhong Nan Da Xue Xue Bao Yi Xue Ban. 30(3): 288-291. PMID: 16045015

Physical State :
Solid
Solubility :
Soluble in ethanol (50 mg/ml), water (0.028 mg/ml at 24° C), methanol, and chloroform.
保存方法 :
Store at 4° C
Melting Point :
97° C (lit.)
Boiling Point :
580.4° C at 760 mmHg
Density :
~1.3 g/cm3 (Predicted)
Refractive Index :
n20D 1.63 (Predicted)
IC50 :
AOX1: IC50 = 33 nM (human); Aldehyde oxidase: IC50 = 740 nM (rat); Pleiotropic ABC efflux transporter of multiple drugs: IC50 = 1.4 µM (Saccharomyces cerevisiae S288c); Plasmodium falciparum: IC50 = 2.51 µM; HERG: IC50 = 4.22 µM (human)
Ki Data :
SR-7: Ki= 23 nM (human); HERG: Ki= 3.45 µM (human)
pK Values :
pKa: 7.39, pKb: 7.94 (Predicted)
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WGK Germany :
3
PubChem CID :
4748
Merck Index :
14: 7183
MDL Number :
MFCD00056798
EC Number :
200-381-5
SMILES :
C1CN(CCN1CCCN2C3=CC=CC=C3SC4=C2C=C(C=C4)Cl)CCO

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