Perindoprilat (CAS 95153-31-4)

(0)

別名: (2S,3aS,7aS)-1-[(2S)-2-[[(1S)-1-Carboxybutyl]amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; [2S-[1[R*(R*)],2α,3aβ,7aβ]]-1-[2-[(1-Carboxybutyl)amino]-1-oxopropyl]octahydro-1H-indole-2-carboxylic Acid; S 9780; USP Perindopril Related Compound B

アプリケーション： Perindoprilat is an angiotensin-converting enzyme (ACE) inhibitor

CAS 番号: 95153-31-4

Molecular Weight: 340.41

Molecular Formula: C₁₇H₂₈N₂O₅

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

* Refer to Certificate of Analysis for lot specific data (including water content).

クイックリンク

画像又はボタンをクリックして、拡大する

Perindoprilat is an active metabolite of Perindopril (sc-205799), an ACE (angiotensin converting enzyme) inhibitor, which modulates the activity of low density lipoprotein receptor-related protein (LRP). LRP is a multifunctional endocytic receptor, which functions in the turnover of proteases and the degradation of extracellular matrix proteins. It is known that Perindoprilat inhibits the conversion of angiotensin I into angiotensin II, which lowers arteriolar pressure and increases venous capacity.

参考文献

1. Bree, F., et al. 1992. Int J Clin Pharmacol Ther Toxicol. 30: 325-330. PMID: 1330941
2. Pawluczyk, I.Z., et al. 2008. J. Biol. Chem. 283: 4588-4594. PMID: 18156630

Physical State :

Solid

Solubility :

Soluble in ethanol, methanol, and water.

保存方法 :

Store at -20° C

Melting Point :

136-140° C

Boiling Point :

~568.1° C at 760 mmHg (Predicted)

Density :

~1.2 g/cm³ (Predicted)

Refractive Index :

n²⁰_D 1.54 (Predicted)

pK Values :

pK_a: 2.27 (Predicted), pK_b: 8.13 (Predicted)

試験・研究用以外には使用しないでください。臨床及び体外診断には使用できません。

RTECS :

ND6007250

PubChem CID :

72022

MDL Number :

MFCD00865777

SMILES :

CCC[[email protected]@H](C(=O)O)N[[email protected]@H](C)C(=O)N1[[email protected]]2CCCC[[email protected]]2C[[email protected]]1C(=O)O

Download SDS (MSDS)

分析表

Adobe Acrobat Reader is required to reliably view,
print and comment on PDF documents

Perindoprilat (CAS 95153-31-4) 参考文献

他の人がPerindoprilat (CAS 95153-31-4)をどのように使用したかをご覧ください。エントリをクリックして、PubMedエントリを表示します。 .

引用 1 to 4 of 4 合計

PMID: # 28666228 van der Nagel, BCH. et al. 2017. J. Chromatogr. B Analyt. Technol. Biomed. Life Sci. 1060: 367-373.

PMID: # 27422988 Flavahan, S. et al. 2016. Am. J. Physiol. Heart Circ. Physiol. 311: H849-54.

PMID: # 25485905 Zhao, Y. et al. 2015. Am. J. Physiol. Heart Circ. Physiol. 308: H358-63.

PMID: # 21411099 Shintani, Y. et al. 2011. Atherosclerosis. 216: 307-12.

引用 1 to 4 of 4 合計

Choose a Store

Choose a Language

Choose a Currency