Molecular structure of PD 123319 ditrifluoroacetate, CAS Number: 130663-39-7
PD 123319 ditrifluoroacetate (CAS 130663-39-7)
See product citations (5)
Application:
PD 123319 ditrifluoroacetate is a selective non-peptide angiotensin AT2 receptor antagonist
CAS Number:
130663-39-7
Purity:
≥99%
Molecular Weight:
736.67
Molecular Formula:
C31H32N4O3•2CF3CO2H
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
PD 123319 ditrifluoroacetate is a potent, selective non-peptide angiotensin AT2 receptor antagonist. Tested on rat adrenal tissue and brain. This compound prevents the binding of angiotensin II to the receptor, which blocks signal transduction and causes vasodilation.
PD 123319 ditrifluoroacetate (CAS 130663-39-7) References
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- Involvement of Src tyrosine kinase and mitogen-activated protein kinase in the facilitation of calcium channels in rat nucleus of the tractus solitarius by angiotensin II. | Endoh, T. 2005. J Physiol. 568: 851-65. PMID: 16123104
- Synthesis and structure-activity relationships of a novel series of non-peptide angiotensin II receptor binding inhibitors specific for the AT2 subtype. | Blankley, CJ., et al. 1991. J Med Chem. 34: 3248-60. PMID: 1956044
- Endogenous angiotensin II facilitates GABAergic neurotransmission afferent to the Na+-responsive neurons of the rat median preoptic nucleus. | Henry, M., et al. 2009. Am J Physiol Regul Integr Comp Physiol. 297: R783-92. PMID: 19587111
- Direct evidence of intracrine angiotensin II signaling in neurons. | Deliu, E., et al. 2014. Am J Physiol Cell Physiol. 306: C736-44. PMID: 24401846
- Angiotensin-(1-7) protects against the development of aneurysmal subarachnoid hemorrhage in mice. | Shimada, K., et al. 2015. J Cereb Blood Flow Metab. 35: 1163-8. PMID: 25757758
- Angiotensin II control of regional haemodynamics in rats with aortocaval fistula. | Duggan, DJ. and Tabrizchi, R. 2016. Exp Physiol. 101: 1192-1205. PMID: 27427425
- Angiotensin II Induces Oxidative Stress and Endothelial Dysfunction in Mouse Ophthalmic Arteries via Involvement of AT1 Receptors and NOX2. | Birk, M., et al. 2021. Antioxidants (Basel). 10: PMID: 34439486
- Captopril inhibits angiogenesis and slows the growth of experimental tumors in rats. | Volpert, OV., et al. 1996. J Clin Invest. 98: 671-9. PMID: 8698858
- Selective blockade of AT1 angiotensin II receptors abolishes ischemic preconditioning in isolated rabbit hearts. | Diaz, RJ. and Wilson, GJ. 1997. J Mol Cell Cardiol. 29: 129-39. PMID: 9040028
- ANG II modifies cardiomyocyte function via extracardiac and intracardiac neurons: in situ and in vitro studies. | Horackova, M. and Armour, JA. 1997. Am J Physiol. 272: R766-75. PMID: 9087638
- AT1 receptors mediate angiotensin II uptake and transport by bovine brain microvessel endothelial cells in primary culture. | Rose, JM. and Audus, KL. 1999. J Cardiovasc Pharmacol. 33: 30-5. PMID: 9890393
Inhibitor of:
Angiogenesis, AT2, and MAS1L.Activator of:
MAS1.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
PD 123319 ditrifluoroacetate, 10 mg | sc-204835 | 10 mg | $213.00 | |||
PD 123319 ditrifluoroacetate, 50 mg | sc-204835A | 50 mg | $843.00 |