p-p120 Antibody (pS268.9A): sc-293000

p-p120 Antibody (pS268.9A) is a mouse monoclonal IgG2b antibody that detects p120 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). p120, also known as cadherin-associated Src substrate, is a crucial protein that plays a significant role in cellular adhesion and signaling pathways. p120 is a 968 amino acid tyrosine kinase substrate belonging to the beta-catenin family and is primarily expressed in vascular endothelium, where p120 localizes to the cytoplasm, nucleus, and cell membrane. p120 mediates ligand-induced receptor signaling through various growth factor receptors, including epidermal growth factor (EGF), platelet-derived growth factor (PDGF), colony-stimulating factor 1 (CSF-1), and Neu receptors. p120 exhibits sequence homology with catenins at four distinct domains, which allows p120 to interact with E-cadherin complexes, thereby influencing cell adhesion and communication. p120 has four major isoforms, each generated through alternative splicing, and contains ten ARM repeats, which are critical for structural integrity and function. p120 undergoes phosphorylation following translation, a post-translational modification that can regulate activity and interactions, making p120 an essential component in the modulation of cellular processes. p-p120 (pS268.9A) monoclonal antibody is an invaluable tool for researchers studying the dynamics of cell adhesion and signaling in various biological contexts.

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p-p120 Antibody (pS268.9A) References:

1. Cell adhesion properties and effects on receptor-mediated insulin endocytosis are independent properties of pp120, a substrate of the insulin receptor tyrosine kinase.  |  Soni, P., et al. 1999. Mol Cell Biol Res Commun. 1: 102-8. PMID: 10356358
2. Comparison of the intracellular trafficking of two alternatively spliced isoforms of pp120, a substrate of the insulin receptor tyrosine kinase.  |  Choice, CV., et al. 1999. J Cell Biochem. 76: 133-42. PMID: 10581007
3. p120, a novel substrate of protein tyrosine kinase receptors and of p60v-src, is related to cadherin-binding factors beta-catenin, plakoglobin and armadillo.  |  Reynolds, AB., et al. 1992. Oncogene. 7: 2439-45. PMID: 1334250
4. p120-catenin mediates inflammatory responses in the skin.  |  Perez-Moreno, M., et al. 2006. Cell. 124: 631-44. PMID: 16469707
5. p120-catenin and p190RhoGAP regulate cell-cell adhesion by coordinating antagonism between Rac and Rho.  |  Wildenberg, GA., et al. 2006. Cell. 127: 1027-39. PMID: 17129786
6. PP120. Hydatidiform mole as a cause of eclampsia in the first trimester: A case report.  |  Ottanelli, S., et al. 2012. Pregnancy Hypertens. 2: 304. PMID: 26105442
7. Molecular cloning of pp120/ECTO-ATPase, an endogenous substrate of the insulin receptor kinase.  |  Najjar, SM., et al. 1993. Adv Exp Med Biol. 343: 169-74. PMID: 8184737
8. The gene encoding p120cas, a novel catenin, localizes on human chromosome 11q11 (CTNND) and mouse chromosome 2 (Catns).  |  Reynolds, AB., et al. 1996. Genomics. 31: 127-9. PMID: 8808291
9. Thymocyte activation induces the association of phosphatidylinositol 3-kinase and pp120 with CD5.  |  Dennehy, KM., et al. 1997. Eur J Immunol. 27: 679-86. PMID: 9079809
10. The expression of p120ctn protein in breast cancer is independent of alpha- and beta-catenin and E-cadherin.  |  Dillon, DA., et al. 1998. Am J Pathol. 152: 75-82. PMID: 9422525
11. Molecular cloning of the human p120ctn catenin gene (CTNND1): expression of multiple alternatively spliced isoforms.  |  Keirsebilck, A., et al. 1998. Genomics. 50: 129-46. PMID: 9653641
12. Chromosomal mapping of human armadillo genes belonging to the p120(ctn)/plakophilin subfamily.  |  Bonné, S., et al. 1998. Genomics. 51: 452-4. PMID: 9721216

The preferred p120 antibody is p120 Antibody (15D2): sc-23872.