p-Cofilin 1 Antibody (F-11): sc-365882

p-Cofilin 1 Antibody (F-11) is a mouse monoclonal IgG2b kappa light chain antibody that detects Ser 3 phosphorylated Cofilin 1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). p-Cofilin 1 (F-11) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Cofilin 1 plays a crucial role in actin dynamics by regulating the turnover and organization of the actin cytoskeleton, which is essential for various cellular processes such as motility, division, and shape maintenance. The phosphorylation of Cofilin 1 at Serine 3, mediated by LIM-kinase 1 (LIMK-1), inhibits actin-depolymerizing activity, thereby stabilizing actin filaments and promoting the formation of a robust cytoskeletal network. This regulatory mechanism is vital for maintaining cellular architecture and responding to signaling pathways that dictate cytoskeletal rearrangements. Anti-p-Cofilin 1 antibody (F-11) enables researchers to gain insights into the intricate balance of actin dynamics and its implications in cellular functions and disease states.

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p-Cofilin 1 Antibody (F-11) References:

1. Cofilin-1 in the podocyte: a molecular switch for actin dynamics.  |  Berger, K. and Moeller, MJ. 2011. Int Urol Nephrol. 43: 273-5. PMID: 21336536
2. c‑Maf inducing protein inhibits cofilin‑1 activity and alters podocyte cytoskeleton organization.  |  Yu, L., et al. 2017. Mol Med Rep. 16: 4955-4963. PMID: 28791377
3. Thapsigargin induces apoptosis of prostate cancer through cofilin-1 and paxillin.  |  Huang, F., et al. 2018. Oncol Lett. 16: 1975-1980. PMID: 30008891
4. Changes in Vasodilator-Stimulated Phosphoprotein Phosphorylation, Profilin-1, and Cofilin-1 in Accreta and Protection by DHA.  |  Ali, M., et al. 2019. Reprod Sci. 26: 757-765. PMID: 30092744
5. Diallyl disulfide induces downregulation and inactivation of cofilin 1 differentiation via the Rac1/ROCK1/LIMK1 pathway in leukemia cells.  |  Ling, H., et al. 2020. Int J Oncol. 56: 772-782. PMID: 32124958
6. Cofilin-1 Is a Mechanosensitive Regulator of Transcription.  |  Domingues, C., et al. 2020. Front Cell Dev Biol. 8: 678. PMID: 32903827
7. TGF-β1 induces amoeboid-to-mesenchymal transition of CD44high oral squamous cell carcinoma cells via miR-422a downregulation through ERK activation and Cofilin-1 phosphorylation.  |  Yokoyama, S., et al. 2021. J Oral Pathol Med. 50: 155-164. PMID: 33107637
8. Up-regulation of cofilin-1 in cell senescence associates with morphological change and p27kip1 -mediated growth delay.  |  Tsai, CH., et al. 2021. Aging Cell. 20: e13288. PMID: 33336885
9. The non-muscle ADF/cofilin-1 controls sarcomeric actin filament integrity and force production in striated muscle laminopathies.  |  Vignier, N., et al. 2021. Cell Rep. 36: 109601. PMID: 34433058
10. Cofilin 1 Is Dynamically Modulated During Postnatal Development and by Visual Input in the Mouse Visual Cortex.  |  Laguardia, A., et al. 2023. Neuroscience. 510: 147-156. PMID: 36470478

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-p-Cofilin 1 Antibody (F-11) has 4 citations in a variety of scientific publications.

Primary antibodies like Anti-p-Cofilin 1 Antibody (F-11) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

p-Cofilin 1 Antibody (F-11) Specifications

Alternate Product Name: Cofilin

Product Clone Name: F-11

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: Ser 3

Epitope Target: Cofilin 1

Epitope Species: mouse

Product Reactivity/Detection: Ser 3 phosphorylated Cofilin 1

Species Reactivity/Detection: mouse, rat, human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, IHC(P), ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 4 citations in various scientific publications

Available Conjugates/Forms for p-Cofilin 1 Antibody (F-11): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred Cofilin antibody is Cofilin Antibody (E-8): sc-376476.