oligophrenin-1 Antibody (E-8): sc-376462

oligophrenin-1 Antibody (E-8) is a mouse monoclonal IgG2a antibody that detects oligophrenin-1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Oligophrenin-1 plays a crucial role as a RhoGAP protein, stimulating the GTP hydrolysis of Rho subfamily members, which is essential for regulating various cellular processes including cell migration, morphogenesis, and axon outgrowth. Anti-oligophrenin-1 antibody (E-8) helps researchers understand how oligophrenin-1 modulates Rho GTPases, particularly in neuronal development and function, as this protein influences cytoskeleton dynamics and cellular signaling pathways. Through GTP hydrolysis facilitation, oligophrenin-1 maintains the balance between active and inactive Rho proteins, ensuring proper cellular responses to external stimuli. Anti-oligophrenin-1 antibody (E-8) serves as an invaluable tool for studying cell signaling and development mechanisms, providing insights into Rho GTPases′ roles in health and disease.

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oligophrenin-1 Antibody (E-8) References:

1. The RhoGAP activity of OPHN1, a new F-actin-binding protein, is negatively controlled by its amino-terminal domain.  |  Fauchereau, F., et al. 2003. Mol Cell Neurosci. 23: 574-86. PMID: 12932438
2. The Rho-linked mental retardation protein OPHN1 controls synaptic vesicle endocytosis via endophilin A1.  |  Nakano-Kobayashi, A., et al. 2009. Curr Biol. 19: 1133-9. PMID: 19481455
3. The Rho-linked mental retardation protein oligophrenin-1 controls synapse maturation and plasticity by stabilizing AMPA receptors.  |  Nadif Kasri, N., et al. 2009. Genes Dev. 23: 1289-302. PMID: 19487570
4. A circadian clock in hippocampus is regulated by interaction between oligophrenin-1 and Rev-erbα.  |  Valnegri, P., et al. 2011. Nat Neurosci. 14: 1293-301. PMID: 21874017
5. Targeted phosphotyrosine profiling of glycoprotein VI signaling implicates oligophrenin-1 in platelet filopodia formation.  |  Bleijerveld, OB., et al. 2013. Arterioscler Thromb Vasc Biol. 33: 1538-43. PMID: 23619296
6. Fasudil treatment in adult reverses behavioural changes and brain ventricular enlargement in Oligophrenin-1 mouse model of intellectual disability.  |  Meziane, H., et al. 2016. Hum Mol Genet. 25: 2314-2323. PMID: 27146843
7. Oligophrenin-1 regulates number, morphology and synaptic properties of adult-born inhibitory interneurons in the olfactory bulb.  |  Redolfi, N., et al. 2016. Hum Mol Genet. 25: 5198-5211. PMID: 27742778
8. Expanding the phenotypic spectrum associated with OPHN1 mutations: Report of 17 individuals with intellectual disability but no cerebellar hypoplasia.  |  Moortgat, S., et al. 2018. Eur J Med Genet. 61: 442-450. PMID: 29510240
9. Novel unconventional variants expand the allelic spectrum of OPHN1 gene.  |  Nuovo, S., et al. 2021. Am J Med Genet A. 185: 1575-1581. PMID: 33638601
10. Hippocampal Excitatory Synaptic Transmission and Plasticity Are Differentially Altered during Postnatal Development by Loss of the X-Linked Intellectual Disability Protein Oligophrenin-1.  |  Cresto, N., et al. 2022. Cells. 11: PMID: 35563851

The preferred oligophrenin-1 antibody is oligophrenin-1 Antibody (A-12): sc-374330.