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Noscapine hydrochloride (CAS 912-60-7)

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Alternate Names:
Narcotine hydrochloride
Application:
Noscapine hydrochloride is a bradykinin B and tubulin inhibitor
CAS Number:
912-60-7
Purity:
≥98%
Molecular Weight:
449.88
Molecular Formula:
C22H23NO7•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.

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Noscapine hydrochloride functions as a microtubule-modulating agent. It acts by binding to tubulin, leading to the inhibition of microtubule dynamics and interfering with the normal assembly and disassembly of microtubules. This disruption ultimately results in the suppression of mitosis and cell division. By targeting the cytoskeleton, Noscapine hydrochloride affects the structural integrity and function of cells, impacting processes such as cell migration and intracellular transport. Its mechanism of action involves the induction of apoptosis and the inhibition of angiogenesis, which may have implications for various cellular processes. Noscapine hydrochloride may act to exhibit potential anti-tumor activity in preclinical studies, making it a subject of interest in cancer research. Its ability to modulate microtubule dynamics and interfere with cellular processes may be useful for investigating the mechanisms underlying cell division and migration.


Noscapine hydrochloride (CAS 912-60-7) References

  1. Noscapine hydrochloride disrupts the mitotic spindle in mammalian cells and induces aneuploidy as well as polyploidy in cultured human lymphocytes.  |  Schuler, M., et al. 1999. Mutagenesis. 14: 51-6. PMID: 10474821
  2. Enhancing the in vitro and in vivo detection of aneuploidy by fluorescence in situ hybridization with the use of bromodeoxyuridine as a proliferation marker.  |  Balakrishnan, S., et al. 2002. Mutat Res. 521: 81-9. PMID: 12438006
  3. Noscapine hydrochloride-induced numerical aberrations in cultured human lymphocytes: a comparison of FISH detection methods and multiple end-points.  |  Schuler, M., et al. 2003. Mutagenesis. 18: 235-42. PMID: 12714688
  4. Relative bioavailability in man of noscapine administered in lozenges and mixture.  |  Jensen, LN., et al. 1992. Acta Pharm Nord. 4: 309-12. PMID: 1294188
  5. Morphological transformation of an established Syrian hamster dermal cell with the anti-tussive agent noscapine.  |  Porter, R., et al. 1992. Mutagenesis. 7: 205-9. PMID: 1602976
  6. Antitumor activity of noscapine in human non-small cell lung cancer xenograft model.  |  Jackson, T., et al. 2008. Cancer Chemother Pharmacol. 63: 117-26. PMID: 18338172
  7. Investigations into the induction of aneuploidy and polyploidy in mammalian cells by the anti-tussive agent noscapine hydrochloride.  |  Gatehouse, DG., et al. 1991. Mutagenesis. 6: 279-83. PMID: 1943718
  8. Radiolabeling, biodistribution and gamma scintigraphy of noscapine hydrochloride in normal and polycystic ovary induced rats.  |  Priyadarshani, A., et al. 2010. J Ovarian Res. 3: 10. PMID: 20420718
  9. Development and validation of an in vitro micronucleus assay platform in TK6 cells.  |  Sobol, Z., et al. 2012. Mutat Res. 746: 29-34. PMID: 22445949
  10. Formulation approaches to improving the delivery of an antiviral drug with activity against seasonal flu.  |  Sammeta, SM., et al. 2015. Pharm Dev Technol. 20: 169-75. PMID: 24218989
  11. A new azo-azomethine sensor for detection of CN- and AcO- anions: Highly selective chemosensor for naked eye detection of sodium diclofenac.  |  Dini, S. and Khanmohammadi, H. 2019. Spectrochim Acta A Mol Biomol Spectrosc. 222: 117157. PMID: 31203052
  12. Noscapine hydrochloride (benzyl-isoquinoline alkaloid) effectively prevents protein denaturation through reduction of IL-6, NF-kB, COX-2, Prostaglandin-E2 in rheumatic rats.  |  Akhter, S., et al. 2022. Saudi Pharm J. 30: 1791-1801. PMID: 36601515
  13. Comparative bioavailability and pharmacokinetics of noscapine hydrogen embonate and noscapine hydrochloride.  |  Haikala, V., et al. 1986. Eur J Clin Pharmacol. 31: 367-9. PMID: 3792437
  14. Determination of noscapine, hexylresorcinol and anethole in cough lozenges by liquid chromatography.  |  Lucangioli, S., et al. 1996. Boll Chim Farm. 135: 387-90. PMID: 8942066

Ordering Information

Product NameCatalog #UNITPriceQtyFAVORITES

Noscapine hydrochloride, 100 mg

sc-203650
100 mg
$20.00

Noscapine hydrochloride, 1 g

sc-203650A
1 g
$67.00