NFATc4 Antibody (F-3): sc-271091

NFATc4 Antibody (F-3) is a mouse monoclonal IgG2b antibody that detects NFATc4 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). NFATc4, or nuclear factor of activated T cells, cytoplasmic, calcineurin-dependent 4, is a crucial transcription factor that plays a significant role in regulating cytokine gene expression, particularly in T cells, where NFATc4 is essential for the inducible expression of cytokines like IL-2 and IL-4. NFATc4 is located primarily in the cytoplasm and translocates to the nucleus upon T cell receptor stimulation, a process that is vital for the activation of immune responses. This translocation is not only critical for T cell function but also influences various physiological processes, including cardiac hypertrophy and adipocyte differentiation. Additionally, NFATc4 is subject to post-translational modifications, such as phosphorylation by p38 MAP kinase, which modulates NFATc4 activity and stability, further underscoring NFATc4′s importance in cellular signaling pathways. Through interactions with other members of the NFAT family, NFATc4 is integral to the formation of the transcription complex that governs immune responses, making anti-NFATc4 antibody (F-3) an invaluable tool for researchers studying T cell biology and related fields.

The preferred NFATc4 antibody is NFATc4 Antibody (B-2): sc-271597.