neuropilin-2 Antibody (C-9): sc-13117
- neuropilin-2 Antibody (C-9) is a mouse monoclonal IgG2b κ neuropilin-2 antibody, cited in 59 publications, provided at 200 µg/ml
- raised against amino acids 560-858 of neuropilin-2 of human origin
- neuropilin-2 Antibody (C-9) is recommended for detection of neuropilin-2 of mouse, rat and human origin by WB, IP, IF, IHC(P) and ELISA
- Anti-neuropilin-2 Antibody (C-9) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2b BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for neuropilin-2 Antibody (C-9) for WB and IHC(P) applications. These reagents are now offered in bundles with neuropilin-2 Antibody (C-9) (see ordering information below).
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neuropilin-2 Antibody (C-9) is a mouse monoclonal IgG2b kappa light chain antibody that detects neuropilin-2 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). neuropilin-2 Antibody (C-9) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. Neuropilin-2, a type I transmembrane receptor, plays a crucial role in axon growth and guidance, acting as a high-affinity receptor for class III semaphorins and vascular endothelial growth factor (VEGF). Neuropilin-2 is particularly important in regulating physiological pathways such as angiogenesis and neural development. Neuropilin-2 is known to undergo polysialylation, a post-translational modification that enhances interaction with ligands and influences function in cellular signaling. Neuropilin-2 expression on dendritic cells and presence in venous and lymphatic endothelium highlight significance in immune responses and vascular biology. In contrast, neuropilin-1 is predominantly expressed in arterial endothelium, indicating a functional divergence between these proteins in the vascular system.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
neuropilin-2 Antibody (C-9) References:
- Neuropilins in physiological and pathological angiogenesis. | Staton, CA., et al. 2007. J Pathol. 212: 237-48. PMID: 17503412
- [Advancements in expression of vascular endothelial growth factor receptors in skin diseases]. | Yang, XH., et al. 2007. Zhongguo Yi Xue Ke Xue Yuan Xue Bao. 29: 279-82. PMID: 17536285
- Polysialylated neuropilin-2 is expressed on the surface of human dendritic cells and modulates dendritic cell-T lymphocyte interactions. | Curreli, S., et al. 2007. J Biol Chem. 282: 30346-56. PMID: 17699524
- Role of neuropilin-2 in the immune system. | Schellenburg, S., et al. 2017. Mol Immunol. 90: 239-244. PMID: 28843905
- Inhibition of VEGF binding to neuropilin-2 enhances chemosensitivity and inhibits metastasis in triple-negative breast cancer. | Xu, Z., et al. 2023. Sci Transl Med. 15: eadf1128. PMID: 37134152
- Murine semaphorin D/collapsin is a member of a diverse gene family and creates domains inhibitory for axonal extension. | Püschel, AW., et al. 1995. Neuron. 14: 941-8. PMID: 7748561
- Semaphorin III can function as a selective chemorepellent to pattern sensory projections in the spinal cord. | Messersmith, EK., et al. 1995. Neuron. 14: 949-59. PMID: 7748562
- Axon guidance: a compelling case for repelling growth cones. | Dodd, J. and Schuchardt, A. 1995. Cell. 81: 471-4. PMID: 7758101
- The semaphorin genes encode a family of transmembrane and secreted growth cone guidance molecules. | Kolodkin, AL., et al. 1993. Cell. 75: 1389-99. PMID: 8269517
- The guidance molecule semaphorin III is expressed in regions of spinal cord and periphery avoided by growing sensory axons. | Wright, DE., et al. 1995. J Comp Neurol. 361: 321-33. PMID: 8543665
- Neuropilin is a receptor for the axonal chemorepellent Semaphorin III. | He, Z. and Tessier-Lavigne, M. 1997. Cell. 90: 739-51. PMID: 9288753
- Neuropilin is a semaphorin III receptor. | Kolodkin, AL., et al. 1997. Cell. 90: 753-62. PMID: 9288754
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
neuropilin-2 Antibody (C-9) | sc-13117 | 200 µg/ml | $322.00 | |||
neuropilin-2 Antibody (C-9): m-IgG Fc BP-HRP Bundle | sc-528261 | 200 µg Ab; 10 µg BP | $361.00 | |||
neuropilin-2 Antibody (C-9): m-IgGκ BP-HRP Bundle | sc-520594 | 200 µg Ab, 40 µg BP | $361.00 | |||
neuropilin-2 Antibody (C-9): m-IgG2b BP-HRP Bundle | sc-550015 | 200 µg Ab; 10 µg BP | $361.00 | |||
neuropilin-2 Antibody (C-9) AC | sc-13117 AC | 500 µg/ml, 25% agarose | $424.00 | |||
neuropilin-2 Antibody (C-9) HRP | sc-13117 HRP | 200 µg/ml | $322.00 | |||
neuropilin-2 Antibody (C-9) FITC | sc-13117 FITC | 200 µg/ml | $336.00 | |||
neuropilin-2 Antibody (C-9) PE | sc-13117 PE | 200 µg/ml | $349.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 488 | sc-13117 AF488 | 200 µg/ml | $364.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 546 | sc-13117 AF546 | 200 µg/ml | $364.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 594 | sc-13117 AF594 | 200 µg/ml | $364.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 647 | sc-13117 AF647 | 200 µg/ml | $364.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 680 | sc-13117 AF680 | 200 µg/ml | $364.00 | |||
neuropilin-2 Antibody (C-9) Alexa Fluor® 790 | sc-13117 AF790 | 200 µg/ml | $364.00 |