m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred secondary detection reagent for Myotrophin Antibody (D-3) for WB applications. This reagent is now offered in a bundle with Myotrophin Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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Myotrophin Antibody (D-3) is a high quality monoclonal Myotrophin antibody (also designated Myotrophin antibody) suitable for the detection of the Myotrophin protein of mouse, rat and human origin. Myotrophin Antibody (D-3) is available as both the non-conjugated anti-Myotrophin antibody form, as well as multiple conjugated forms of anti-Myotrophin antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. Myotrophin (V-1 protein) is a ubiquitously expressed cytoplasmic protein that can translocate to the nucleus during sustained NFκB activation. The gene encoding for this protein localizes to chromosome 7q33. Myotrophin may be involved in cerebellar morphogenesis and contains an acetylated N-terminus and 2.5 internal 33 amino acid ankyrin repeats. It is important in the differentiation of cerebellar neurons, particularly of granule cells. The 117 amino acid protein has been associated with, and able to induce, cardiac hypertrophy. Myotrophin increases protooncogene, ANF and β-Myosin heavy chain transcript levels. Myotrophin is upregulated when myocytes undergo cyclic stretch or are treated with tumor necrosis factor α (TNFα) or interleukin-1β. Highest levels of Myotrophin are detected in brain and lowest levels in skeletal muscle.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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