Molecular structure of Minocycline, Hydrochloride, CAS Number: 13614-98-7
Minocycline, Hydrochloride (CAS 13614-98-7)
See product citations (36)
Alternate Names:
Minocycline, Hydrochloride is also known as 7-Dimethylamino-6-demethyl-6-deoxytetracycline, HCl.
Application:
Minocycline, Hydrochloride is a broad-spectrum tetracycline antibiotic that also acts as PARP inhibitor.
CAS Number:
13614-98-7
Purity:
≥98%
Molecular Weight:
493.94
Molecular Formula:
C23H27N3O7•HCl
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Minocycline, Hydrochloride is a tetracycline compound with anticollagenase, antimicrobial, and anti-inflammatory properties. Minocycline, Hydrochloride has been reported to inhibit the enzymatic activity of poly(ADP-ribose) polymerase-1 (PARP-1) and angiogenesis. Studies show that Doxycycline is an analog of Minocycline, Hydrochloride and that both act as metalloproteinase inhibitors. In addition, Minocycline, Hydrochloride is suggested to down-regulate CD40L on T cells and inhibit the replication of SIV and HIV.
Minocycline, Hydrochloride (CAS 13614-98-7) References
- Minocycline attenuates T cell and microglia activity to impair cytokine production in T cell-microglia interaction. | Giuliani, F., et al. 2005. J Leukoc Biol. 78: 135-43. PMID: 15817702
- Neuroprotective and anti-human immunodeficiency virus activity of minocycline. | Zink, MC., et al. 2005. JAMA. 293: 2003-11. PMID: 15855434
- Angiogenesis inhibition by minocycline. | Tamargo, RJ., et al. 1991. Cancer Res. 51: 672-5. PMID: 1702361
- Minocycline protects cardiac myocytes against simulated ischemia–reperfusion injury by inhibiting poly(ADP-ribose) polymerase-1. | Tao, R., et al. 2010. J Cardiovasc Pharmacol. 56: 659-68. PMID: 20881608
- Intrapleural minocycline pleurodesis for the treatment of primary spontaneous pneumothorax. | Chen, JS., et al. 2014. Curr Opin Pulm Med. 20: 371-6. PMID: 24852327
- Efficacy and tolerability of minocycline augmentation therapy in schizophrenia: a systematic review and meta-analysis of randomized controlled trials. | Oya, K., et al. 2014. Hum Psychopharmacol. 29: 483-91. PMID: 25087702
- Rapid response of tattoo-associated cutaneous sarcoidosis to minocycline: case report and review of the literature. | Sheu, J., et al. 2014. Dermatol Online J. 20: PMID: 25148277
- A review of intravenous minocycline for treatment of multidrug-resistant Acinetobacter infections. | Ritchie, DJ. and Garavaglia-Wilson, A. 2014. Clin Infect Dis. 59 Suppl 6: S374-80. PMID: 25371513
- Protocol and rationale-the efficacy of minocycline as an adjunctive treatment for major depressive disorder: a double blind, randomised, placebo controlled trial. | Dean, OM., et al. 2014. Clin Psychopharmacol Neurosci. 12: 180-8. PMID: 25598820
- On the prescribing of oral doxycycline or minocycline by UK optometrists as part of management of chronic Meibomian Gland Dysfunction (MGD). | Doughty, MJ. 2016. Cont Lens Anterior Eye. 39: 2-8. PMID: 26347083
- The tetracycline analogs minocycline and doxycycline inhibit angiogenesis in vitro by a non-metalloproteinase-dependent mechanism. | Gilbertson-Beadling, S., et al. 1995. Cancer Chemother Pharmacol. 36: 418-24. PMID: 7543375
- The influence of tetracyclines on T cell activation. | Kloppenburg, M., et al. 1995. Clin Exp Immunol. 102: 635-41. PMID: 8536384
- Antiangiogenic therapy of transgenic mice impairs de novo tumor growth. | Parangi, S., et al. 1996. Proc Natl Acad Sci U S A. 93: 2002-7. PMID: 8700875
Inhibitor of:
γ-FR, AFMID, Angiogenesis, Caytaxin, COL12A1, CPM, CRABP-II, ENDOG, ERAL1, Huntingtin, Iba1, MMP-10, MMP-3, MRP-L1, NgR3, PARP-1, PCLN-1, Serine racemase, SPR, and TIMP-4.Activator of:
LUZP4, MMP-19, and SSTK-IP.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Minocycline, Hydrochloride, 50 mg | sc-203339 | 50 mg | $52.00 | |||
Minocycline, Hydrochloride, 250 mg | sc-203339A | 250 mg | $171.00 | |||
Minocycline, Hydrochloride, 1 g | sc-203339B | 1 g | $281.00 | |||
Minocycline, Hydrochloride, 2.5 g | sc-203339C | 2.5 g | $634.00 | |||
Minocycline, Hydrochloride, 10 g | sc-203339D | 10 g | $1259.00 | |||
Minocycline, Hydrochloride, 100 g | sc-203339E | 100 g | $5836.00 | |||
Minocycline, Hydrochloride, 1 kg | sc-203339F | 1 kg | $24980.00 |