Ly-6C Antibody (HK1.4): sc-13574
- Ly-6C Antibody (HK1.4) is a rat monoclonal IgG2c provided at 200 µg/ml
- raised against L3 cloned CTL cells
- recommended for detection of Ly-6C of mouse origin by IP and IF
- available conjugated to either phycoerythrin or FITC for IF, IHC(P) and FCM
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Ly-6C Antibody (HK1.4). This work is in progress.
Ly-6C Antibody (HK1.4) is a rat monoclonal IgG2c antibody that detects Ly-6C in mouse samples through immunoprecipitation (IP) and immunofluorescence (IF) applications. Ly-6C is a critical protein that plays a significant role in the immune response, particularly in the activation and regulation of CD8 T cells. Anti-Ly-6C antibody (HK1.4) recognizes a protein predominantly expressed on murine peripheral CD8 T cells, where Ly-6C is involved in various essential functions, including endothelial adhesion, the cytotoxic activity of cytotoxic T lymphocytes (CTLs), and the induction of T cell receptor-mediated production of interleukin-2 and interferon-gamma. Ly-6C expression on these T cells is crucial for their homing to sites of inflammation, thereby facilitating an effective immune response. Additionally, Ly-6C may function as a signaling molecule that activates lymphocyte function-associated antigen 1 (LFA-1), which is vital for T cell adhesion and migration. The unique expression patterns of Ly-6C during hematopoiesis and its interaction with other immune cells underscore its importance in maintaining immune system integrity and response.
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Ly-6C Antibody (HK1.4) References:
- Differential Ly-6C expression identifies the recruited macrophage phenotype, which orchestrates the regression of murine liver fibrosis. | Ramachandran, P., et al. 2012. Proc Natl Acad Sci U S A. 109: E3186-95. PMID: 23100531
- Ly-6C(hi) monocytes: a potential target for preventing transplant arteriosclerosis? | Schiopu, A., et al. 2013. Expert Rev Clin Immunol. 9: 5-7. PMID: 23256758
- Macrophage heterogeneity in liver injury and fibrosis. | Tacke, F. and Zimmermann, HW. 2014. J Hepatol. 60: 1090-6. PMID: 24412603
- Origin and functions of tissue macrophages. | Epelman, S., et al. 2014. Immunity. 41: 21-35. PMID: 25035951
- Ly-6C is a monocyte/macrophage and endothelial cell differentiation antigen regulated by interferon-gamma. | Jutila, MA., et al. 1988. Eur J Immunol. 18: 1819-26. PMID: 2849552
- Imbalance of Ly-6Chi and Ly-6Clo Monocytes/Macrophages Worsens Hyperoxia-Induced Lung Injury and Is Rescued by IFN-γ. | Eldredge, LC., et al. 2019. J Immunol. 202: 2772-2781. PMID: 30944158
- Non-classical tissue monocytes and two functionally distinct populations of interstitial macrophages populate the mouse lung. | Schyns, J., et al. 2019. Nat Commun. 10: 3964. PMID: 31481690
- Ly-6Chigh inflammatory-monocyte recruitment is regulated by p38 MAPK/MCP-1 activation and promotes ventilator-induced lung injury. | Zhang, W., et al. 2020. Int Immunopharmacol. 78: 106015. PMID: 31780369
- Impaired Kupffer Cell Self-Renewal Alters the Liver Response to Lipid Overload during Non-alcoholic Steatohepatitis. | Tran, S., et al. 2020. Immunity. 53: 627-640.e5. PMID: 32562600
- Ly-6C regulates endothelial adhesion and homing of CD8(+) T cells by activating integrin-dependent adhesion pathways. | Hänninen, A., et al. 1997. Proc Natl Acad Sci U S A. 94: 6898-903. PMID: 9192663
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ly-6C Antibody (HK1.4) | sc-13574 | 200 µg/ml | $322.00 | |||
Ly-6C Antibody (HK1.4) FITC | sc-13574 FITC | 200 µg/ml | $336.00 | |||
Ly-6C Antibody (HK1.4) PE | sc-13574 PE | 200 µg/ml | $349.00 |