Molecular structure of Ketotifen fumarate, CAS Number: 34580-14-8
Ketotifen fumarate (CAS 34580-14-8)
See product citations (3)
CAS Number:
34580-14-8
Purity:
≥98%
Molecular Weight:
425.5
Molecular Formula:
C19H19NOS•C4H4O4
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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Ketotifen fumarate, a Histamine H1 receptor antagonist, has been noted to inhibit histamine release from lymphocytes and monocytes at 0.1-10 muM. Ketotifen has demonstrated inhibiting characteristics against mast cell growth, therefore reducing myofibroblast hyperplasia. This compound has displayed induction capacities in primary necrosis of interleukin-5-treated eosinophils. Ketotifen fumarate is an inhibitor of PDE.
Ketotifen fumarate (CAS 34580-14-8) References
- Effect of ketotifen fumarate, olopatadine, and levocabastine on ocular active anaphylaxis in the guinea pig and ocular immediate hypersensitivity in the albino rat. | Schoch, C. 2005. Ocul Immunol Inflamm. 13: 39-44. PMID: 15804768
- Ketotifen induces primary necrosis of human eosinophils. | Hasala, H., et al. 2005. J Ocul Pharmacol Ther. 21: 318-27. PMID: 16117696
- The sorption of ketotifen fumarate by chitosan. | Alkhamis, KA., et al. 2008. AAPS PharmSciTech. 9: 866-9. PMID: 18651226
- The mast cell stabilizer ketotifen fumarate lessens contracture severity and myofibroblast hyperplasia: a study of a rabbit model of posttraumatic joint contractures. | Monument, MJ., et al. 2010. J Bone Joint Surg Am. 92: 1468-77. PMID: 20516323
- Ketotifen Fumarate and Salbutamol Sulphate Combined Transdermal Patch Formulations: In vitro release and Ex vivo Permeation Studies. | Yousuf, M., et al. 2013. Indian J Pharm Sci. 75: 569-77. PMID: 24403658
- Topical Olopatadine Hydrochloride versus Ketotifen Fumarate for Allergic Conjunctivitis. | Patel, D., et al. 2018. J Ophthalmic Vis Res. 13: 119-123. PMID: 29719638
- Ketotifen fumarate attenuates feline gingivitis related with gingival microenvironment modulation. | Yuan, W., et al. 2018. Int Immunopharmacol. 65: 159-173. PMID: 30316074
- Effect of ketotifen fumarate on experimental autoimmune orchitis and torsion of the spermatic cord. | Moreno, D., et al. 2020. Asian J Androl. 22: 112-117. PMID: 31115365
- Combination treatment of allergic rhinitis using ketotifen fumarate and budesonide administered as nasal sprays . | Wang, SZ., et al. 2020. Int J Clin Pharmacol Ther. 58: 195-197. PMID: 32068532
- Mast cell stabilizer ketotifen fumarate reverses inflammatory but not neuropathic-induced mechanical pain in mice. | Meloto, CB., et al. 2021. Pain Rep. 6: e902. PMID: 34104835
- Topical Ketotifen Fumarate Inhibits Choroidal Mast Cell Degranulation and Loss of Retinal Pigment Epithelial Cells in Rat Model for Geographic Atrophy. | Nizawa, T., et al. 2021. Transl Vis Sci Technol. 10: 37. PMID: 34967831
- Mechanism of ketotifen fumarate inhibiting renal calcium oxalate stone formation in SD rats. | Huang, Z., et al. 2022. Biomed Pharmacother. 151: 113147. PMID: 35643070
- Use of Ketotifen Fumarate-Eluting Daily Disposable Soft Contact Lens in Management of Ocular Allergy: Literature Review and Report of Two Cases. | Ono, J. and Toshida, H. 2022. Cureus. 14: e27093. PMID: 36000122
- Determining initial ocular comfort differences between 0.7% olopatadine and 0.035% ketotifen fumarate. | Logan, A., et al. 2023. Cont Lens Anterior Eye. 46: 101769. PMID: 36195538
- Comparison of anti-allergic activities of the histamine H1 receptor antagonists epinastine, ketotifen and oxatomide in human leukocytes. | Mita, H. and Shida, T. 1995. Arzneimittelforschung. 45: 36-40. PMID: 7893266
Inhibitor of:
HDC, Histamine H1 Receptor, and PDE.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Ketotifen fumarate, 100 mg | sc-201094A | 100 mg | $46.00 | |||
Ketotifen fumarate, 1 g | sc-201094 | 1 g | $73.00 |