KCNE3 Antibody (G-6): sc-393841
- KCNE3 Antibody (G-6) is a mouse monoclonal IgG2a κ KCNE3 antibody, cited in 1 publications, provided at 200 µg/ml
- specific for an epitope mapping between amino acids 2-27 at the N-terminus of KCNE3 of human origin
- KCNE3 Antibody (G-6) is recommended for detection of KCNE3 of mouse, rat and human origin by WB, IP, IF and ELISA; also reactive with additional species, including and canine and porcine
- Anti-KCNE3 Antibody (G-6) is available conjugated to agarose for IP; HRP for WB, IHC(P) and ELISA; and to either phycoerythrin or FITC for IF, IHC(P) and FCM
- also available conjugated to Alexa Fluor® 488, Alexa Fluor® 546, Alexa Fluor® 594 or Alexa Fluor® 647 for WB (RGB), IF, IHC(P) and FCM, and for use with RGB fluorescent imaging systems, such as iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- also available conjugated to Alexa Fluor® 680 or Alexa Fluor® 790 for WB (NIR), IF and FCM; for use with Near-Infrared (NIR) detection systems, such as LI-COR®Odyssey®, iBright™ FL1000, FluorChem™, Typhoon, Azure and other comparable systems
- m-IgG Fc BP-HRP, m-IgG2a BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for KCNE3 Antibody (G-6) for WB applications. These reagents are now offered in bundles with KCNE3 Antibody (G-6) (see ordering information below).
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KCNE3 Antibody (G-6) is a mouse monoclonal IgG2a kappa light chain antibody that detects KCNE3 of mouse, rat, and human origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). KCNE3 Antibody (G-6) is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. KCNE3, also known as potassium voltage-gated channel, Isk-related family, member 3, plays a crucial role in regulating voltage-gated potassium channels, which are essential for maintaining electrical excitability of neurons and muscle cells. This single-pass type I membrane protein, consisting of 103 amino acids, is predominantly expressed in kidney and is also found in moderate levels in small intestine. KCNE3 associates with voltage-gated potassium channel complexes, influencing their stability and gating kinetics, which is vital for proper cellular function and signaling. The gene encoding KCNE3 is located on human chromosome 11q13.4, and mutations in this gene are linked to several autosomal dominant disorders, including hypokalemic periodic paralysis, thyrotoxic periodic paralysis type 1, and Brugada syndrome type 6, highlighting KCNE3′s importance in both health and disease.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
KCNE3 Antibody (G-6) References:
- MiRP1 forms IKr potassium channels with HERG and is associated with cardiac arrhythmia. | Abbott, GW., et al. 1999. Cell. 97: 175-87. PMID: 10219239
- MiRP2 forms potassium channels in skeletal muscle with Kv3.4 and is associated with periodic paralysis. | Abbott, GW., et al. 2001. Cell. 104: 217-31. PMID: 11207363
- A mutation in the KCNE3 potassium channel gene is associated with susceptibility to thyrotoxic hypokalemic periodic paralysis. | Dias Da Silva, MR., et al. 2002. J Clin Endocrinol Metab. 87: 4881-4. PMID: 12414843
- No mutation in the KCNE3 potassium channel gene in Chinese thyrotoxic hypokalaemic periodic paralysis patients. | Tang, NL., et al. 2004. Clin Endocrinol (Oxf). 61: 109-12. PMID: 15212652
- Phosphorylation and protonation of neighboring MiRP2 sites: function and pathophysiology of MiRP2-Kv3.4 potassium channels in periodic paralysis. | Abbott, GW., et al. 2006. FASEB J. 20: 293-301. PMID: 16449802
- KCNE3 is an inhibitory subunit of the Kv4.3 potassium channel. | Lundby, A. and Olesen, SP. 2006. Biochem Biophys Res Commun. 346: 958-67. PMID: 16782062
- Functional effects of KCNE3 mutation and its role in the development of Brugada syndrome. | Delpón, E., et al. 2008. Circ Arrhythm Electrophysiol. 1: 209-18. PMID: 19122847
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
KCNE3 Antibody (G-6) | sc-393841 | 200 µg/ml | $322.00 | |||
KCNE3 Antibody (G-6): m-IgG Fc BP-HRP Bundle | sc-530599 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNE3 Antibody (G-6): m-IgGκ BP-HRP Bundle | sc-524113 | 200 µg Ab, 40 µg BP | $361.00 | |||
KCNE3 Antibody (G-6): m-IgG2a BP-HRP Bundle | sc-547530 | 200 µg Ab; 10 µg BP | $361.00 | |||
KCNE3 Antibody (G-6) AC | sc-393841 AC | 500 µg/ml, 25% agarose | $424.00 | |||
KCNE3 Antibody (G-6) HRP | sc-393841 HRP | 200 µg/ml | $322.00 | |||
KCNE3 Antibody (G-6) FITC | sc-393841 FITC | 200 µg/ml | $336.00 | |||
KCNE3 Antibody (G-6) PE | sc-393841 PE | 200 µg/ml | $349.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 488 | sc-393841 AF488 | 200 µg/ml | $364.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 546 | sc-393841 AF546 | 200 µg/ml | $364.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 594 | sc-393841 AF594 | 200 µg/ml | $364.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 647 | sc-393841 AF647 | 200 µg/ml | $364.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 680 | sc-393841 AF680 | 200 µg/ml | $364.00 | |||
KCNE3 Antibody (G-6) Alexa Fluor® 790 | sc-393841 AF790 | 200 µg/ml | $364.00 | |||
KCNE3 (G-6) Neutralizing Peptide | sc-393841 P | 100 µg/0.5 ml | $69.00 |