JAB1 Antibody (42): sc-135954
- JAB1 Antibody (42) is a mouse monoclonal IgG1, cited in 2 publications, provided at 50 µg/0.5 ml
- raised against amino acids 234-334 of JAB1 of human origin
- recommended for detection of JAB1 of mouse, rat and human origin by WB, IP and IF
- See JAB1 (B-7): sc-13157 for JAB1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for JAB1 Antibody (42). This work is in progress.
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JAB1 Antibody (42) is a mouse monoclonal IgG1 antibody that detects JAB1 in mouse, rat, and human samples through applications such as western blotting (WB), immunoprecipitation (IP), and immunofluorescence (IF). JAB1, also known as Jun-activation domain-binding protein, plays a crucial role in enhancing the transcriptional activity of Jun proteins by stabilizing their binding to the TPA-response element, which is vital for regulating gene expression in response to various stimuli. JAB1 is primarily located in the nucleus, where JAB1 interacts with c-Jun and Jun D, but not with Jun B or v-Jun, thereby forming specific complexes that modulate transcriptional responses. JAB1′s nuclear localization influences cellular processes such as proliferation, differentiation, and apoptosis, making JAB1 a significant player in oncogenic signaling pathways. JAB1′s interaction with Ha-Ras further augments c-Jun activity, highlighting JAB1′s role in the intricate network of signaling that governs cellular responses to growth factors and stress. The gene encoding JAB1 is mapped to human chromosome 8q12.3, underscoring JAB1′s relevance in both normal physiology and disease states, including cancer.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
JAB1 Antibody (42) References:
- Interactions between HIF-1 and Jab1: balancing apoptosis and adaptation. Outline of a working hypothesis. | Larsen, M., et al. 2005. Adv Exp Med Biol. 566: 203-11. PMID: 16594154
- Jab1 as a mediator of nuclear export and cytoplasmic degradation of p53. | Lee, EW., et al. 2006. Mol Cells. 22: 133-40. PMID: 17085963
- Jab1 promotes glioma cell proliferation by regulating Siah1/β-catenin pathway. | Zhu, Y., et al. 2017. J Neurooncol. 131: 31-39. PMID: 27640199
- Jab1/Cops5 contributes to chemoresistance in breast cancer by regulating Rad51. | Liu, G., et al. 2019. Cell Signal. 53: 39-48. PMID: 30244171
- Jab1 Silencing Inhibits Proliferation and Sensitizes to Cisplatin in Biliary Tract Cancer. | Nam, AR., et al. 2019. Cancer Res Treat. 51: 886-900. PMID: 30282449
- JAB1/COPS5 is a putative oncogene that controls critical oncoproteins deregulated in prostate cancer. | Danielpour, D., et al. 2019. Biochem Biophys Res Commun. 518: 374-380. PMID: 31434609
- Jab1 promotes gastric cancer tumorigenesis via non-ubiquitin proteasomal degradation of p14ARF. | Wang, L., et al. 2020. Gastric Cancer. 23: 1003-1017. PMID: 32458234
- The master developmental regulator Jab1/Cops5/Csn5 is essential for proper bone growth and survival in mice. | Samsa, WE., et al. 2021. Bone. 143: 115733. PMID: 33157284
- The transcriptional cofactor Jab1/Cops5 is crucial for BMP-mediated mouse chondrocyte differentiation by repressing p53 activity. | Mamidi, MK., et al. 2021. J Cell Physiol. 236: 5686-5697. PMID: 33393086
- Alpha5 nicotinic acetylcholine receptor mediated immune escape of lung adenocarcinoma via STAT3/Jab1-PD-L1 signalling. | Zhu, P., et al. 2022. Cell Commun Signal. 20: 121. PMID: 35971127
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
JAB1 Antibody (42) | sc-135954 | 50 µg/0.5 ml | $322.00 |