IP-10 Antibody (E-2): sc-374092

IP-10 Antibody (E-2) is a mouse monoclonal IgG2b kappa light chain antibody that detects IP-10 protein of mouse origin by western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). IP-10 (E-2) antibody is available in both non-conjugated and various conjugated forms, including agarose, horseradish peroxidase (HRP), phycoerythrin (PE), fluorescein isothiocyanate (FITC), and multiple Alexa Fluor® conjugates. IP-10, also known as C-X-C Motif Chemokine Ligand 10, plays a crucial role in the immune response by acting as a chemokine that attracts immune cells to sites of inflammation, thereby facilitating the body′s defense mechanisms against pathogens. IP-10 ability to recruit T cells and other immune cells makes IP-10 essential for the regulation of inflammatory processes and the development of various immune-related diseases. Understanding IP-10 function is vital for developing therapeutic strategies targeting inflammatory conditions, as well as for studying IP-10 role in diseases such as cancer and autoimmune disorders. IP-10 is part of the C-X-C chemokine subfamily, which is characterized by the presence of two cysteine residues separated by an amino acid, distinguishing IP-10 from other chemokine subfamilies.

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IP-10 Antibody (E-2) References:

1. Biology and biochemistry of the chemokines: a family of chemotactic and inflammatory cytokines.  |  Miller, MD. and Krangel, MS. 1992. Crit Rev Immunol. 12: 17-46. PMID: 1418604
2. Distinct roles for IP-10/CXCL10 in three animal models, Theiler's virus infection, EAE, and MHV infection, for multiple sclerosis: implication of differing roles for IP-10.  |  Tsunoda, I., et al. 2004. Mult Scler. 10: 26-34. PMID: 14760949
3. Biology of the RANTES/SIS cytokine family.  |  Schall, TJ. 1991. Cytokine. 3: 165-83. PMID: 1715772
4. Properties of the novel proinflammatory supergene 'intercrine' cytokine family.  |  Oppenheim, JJ., et al. 1991. Annu Rev Immunol. 9: 617-48. PMID: 1910690
5. IP-10/CXCL10 and MIG/CXCL9 as novel markers for the diagnosis of lymphoma-associated hemophagocytic syndrome.  |  Maruoka, H., et al. 2014. Ann Hematol. 93: 393-401. PMID: 23975214
6. Critical Role of IP-10 on Reducing Experimental Corneal Neovascularization.  |  Liu, G., et al. 2015. Curr Eye Res. 40: 891-901. PMID: 25309995
7. IP-10 differentiates between active and latent tuberculosis irrespective of HIV status and declines during therapy.  |  Wergeland, I., et al. 2015. J Infect. 70: 381-91. PMID: 25597826
8. Potential role of type I interferon/IP-10 axis in the pathogenesis of anti-MDA5 antibody-positive dermatomyositis.  |  Kokuzawa, A., et al. 2023. Clin Exp Rheumatol. 41: 275-284. PMID: 36622131
9. Chemokine expression in murine experimental allergic encephalomyelitis.  |  Godiska, R., et al. 1995. J Neuroimmunol. 58: 167-76. PMID: 7539012
10. Review of the chemokine meeting the Third International Symposium of Chemotactic Cytokines.  |  Taub, DD. and Oppenheim, JJ. 1993. Cytokine. 5: 175-9. PMID: 8218927
11. The role of MIP-1 alpha in inflammation and hematopoiesis.  |  Cook, DN. 1996. J Leukoc Biol. 59: 61-6. PMID: 8558069
12. C-C chemokines, but not the C-X-C chemokines interleukin-8 and interferon-gamma inducible protein-10, stimulate transendothelial chemotaxis of T lymphocytes.  |  Roth, SJ., et al. 1995. Eur J Immunol. 25: 3482-8. PMID: 8566041

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-IP-10 Antibody (E-2) has 17 citations in a variety of scientific publications.

Primary antibodies like Anti-IP-10 Antibody (E-2) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

IP-10 Antibody (E-2) Specifications

Alternate Product Name: CXCL10

Product Clone Name: E-2

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG_2b kappa light chain

Amino Acids: 24-55

Epitope Target: IP-10

Epitope Species: mouse

Product Reactivity/Detection: IP-10

Species Reactivity/Detection: mouse

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP, IF, ELISA

Vialing Information: Each vial contains 200 µg IgG_2b kappa light chain in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 17 citations in various scientific publications

Available Conjugates/Forms for IP-10 Antibody (E-2): AC: Agarose, AF488: Alexa Fluor^® 488, AF546: Alexa Fluor^® 546, AF594: Alexa Fluor^® 594, AF647: Alexa Fluor^® 647, AF680: Alexa Fluor^® 680, AF790: Alexa Fluor^® 790, FITC: Fluoroscein, HRP: Horseradish Peroxidase, P: Blocking Peptide, PE: Phycoerythrin

The preferred IP-10 antibody is IP-10 Antibody (1): sc-101500.