Iohexol-d3 (CAS 66108-95-0 (unlabeled))

Iohexol-d3 is a deuterium-labeled version of iohexol, an iodinated contrast agent used in diagnostic imaging. The introduction of deuterium atoms (heavy hydrogen) makes iohexol-d3 an ideal internal standard for analytical methods such as liquid chromatography-tandem mass spectrometry (LC-MS/MS). Researchers utilize iohexol-d3 to calibrate their instruments and validate the accuracy of their assays when measuring the concentration of iohexol in biological samples. The deuterated compound provides a mass shift that allows for the differentiation from the non-labeled iohexol, ensuring precise quantification while maintaining the same chemical properties as the parent molecule. In studies that focus on the mechanisms of iohexol, its distribution, metabolism, and excretion can be characterized with enhanced accuracy by comparing the behavior of iohexol-d3 alongside the non-deuterated form. Additionally, iohexol-d3 serves as useful in research related to kidney function and glomerular filtration rate (GFR) assessment.