Insulin Antibody (C-PEP-01): sc-51647
- Insulin Antibody (C-PEP-01) is a mouse monoclonal IgG1 provided at 100 µg/ml
- raised against C-peptide of human origin conjugated to BSA
- recommended for detection of C-peptide of proinsulin of human origin by WB, IP and ELISA
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Insulin Antibody (C-PEP-01). This work is in progress.
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Insulin Antibody (C-PEP-01) is a mouse monoclonal IgG1 antibody designed to recognize the C-peptide region of human proinsulin. Insulin, a vital peptide hormone composed of 51 amino acids arranged into an A chain and a B chain connected by two disulfide bridges, is essential for regulating glucose uptake and metabolism in the body. The C-peptide serves as a connecting segment between the A and B chains in the precursor molecule proinsulin, playing a crucial role in the proper folding and structural stability of insulin before cleavage to form the mature hormone. This structural configuration ensures the biological activity of insulin, facilitating processes such as increasing cell permeability to monosaccharides, amino acids, and fatty acids. Insulin monoclonal antibody (C-PEP-01) allows for precise detection and quantification of proinsulin and insulin secretion levels, which is essential for studying insulin biosynthesis and secretion dynamics. Anti-Insulin antibody (C-PEP-01) is recommended for use in western blotting (WB), immunoprecipitation (IP), and enzyme-linked immunosorbent assay (ELISA) for the detection of human proinsulin C-peptide, making this tool invaluable for research into insulin-related metabolic processes and disorders, including type-II diabetes mellitus. Insulin (C-PEP-01) antibody specifically binds the C-peptide, ensuring accurate measurements in various experimental settings and supporting advancements in understanding and managing insulin deficiencies and resistances.
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Insulin Antibody (C-PEP-01) References:
- Insulin, nitric oxide and the sympathetic nervous system: at the crossroads of metabolic and cardiovascular regulation. | Sartori, C. and Scherrer, U. 1999. J Hypertens. 17: 1517-25. PMID: 10608463
- Role of the insulin-regulated aminopeptidase IRAP in insulin action and diabetes. | Keller, SR. 2004. Biol Pharm Bull. 27: 761-4. PMID: 15187412
- Spotlight on insulin aspart in type 1 and 2 diabetes mellitus. | Chapman, TM., et al. 2003. Treat Endocrinol. 2: 71-6. PMID: 15871555
- Intermediate and long-acting insulins: a review of NPH insulin, insulin glargine and insulin detemir. | Peterson, GE. 2006. Curr Med Res Opin. 22: 2613-9. PMID: 17166343
- Review of biphasic insulin aspart in the treatment of type 1 and 2 diabetes. | Raja-Khan, N., et al. 2007. Vasc Health Risk Manag. 3: 919-35. PMID: 18200811
- Insulin regulates its own delivery to skeletal muscle by feed-forward actions on the vasculature. | Barrett, EJ., et al. 2011. Am J Physiol Endocrinol Metab. 301: E252-63. PMID: 21610226
- Insulin dysfunction and allostatic load in bipolar disorder. | Brietzke, E., et al. 2011. Expert Rev Neurother. 11: 1017-28. PMID: 21721918
- Biosynthetic Human Insulin and Insulin Analogs. | Rodbard, HW. and Rodbard, D. 2020. Am J Ther. 27: e42-e51. PMID: 31876563
- Insulin biobetters and biosimilars in clinical practice. | Home, P. 2023. J R Coll Physicians Edinb. 53: 147-155. PMID: 37198930
- Human insulin. | Raptis, S. and Dimitriadis, G. 1985. Clin Physiol Biochem. 3: 29-42. PMID: 3888492
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Insulin Antibody (C-PEP-01) | sc-51647 | 100 µg/ml | $322.00 |