I-FABP Antibody (G-5): sc-376070

I-FABP Antibody (G-5) is a mouse monoclonal IgG2a antibody that detects intestinal fatty acid-binding protein (I-FABP) in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry with paraffin-embedded sections (IHCP), and enzyme-linked immunosorbent assay (ELISA). I-FABP plays a crucial role in the absorption and transport of fatty acids within the epithelial cells of the small intestine, which is vital for maintaining lipid homeostasis and energy balance in the body. I-FABP is predominantly expressed in the cytoplasm of enterocytes, where I-FABP facilitates the uptake of dietary fatty acids and their subsequent transport to various cellular compartments for metabolism or storage. I-FABP localization in the intestinal epithelium underscores I-FABP′s importance in nutrient absorption and metabolic regulation, particularly in the context of high-fat diets or metabolic disorders. Additionally, the human I-FABP gene is located on chromosome 4q26 and exhibits a polymorphism at codon 54, which results in two alleles: one encoding alanine and the other encoding threonine. The threonine variant at this position has been linked to enhanced fat oxidation and insulin resistance, highlighting I-FABP′s potential role in metabolic diseases. Anti-I-FABP antibody (G-5) is an essential tool for researchers investigating lipid metabolism, intestinal health, and related metabolic disorders.

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I-FABP Antibody (G-5) References:

1. Is I-FABP not only a marker for the detection abdominal injury but also of hemorrhagic shock in severely injured trauma patients?  |  Voth, M., et al. 2019. World J Emerg Surg. 14: 49. PMID: 31832083
2. Urinary I-FABP, L-FABP, TFF-3, and SAA Can Diagnose and Predict the Disease Course in Necrotizing Enterocolitis at the Early Stage of Disease.  |  Coufal, S., et al. 2020. J Immunol Res. 2020: 3074313. PMID: 32190704
3. I-FABP is decreased in COVID-19 patients, independently of the prognosis.  |  Guedj, K., et al. 2021. PLoS One. 16: e0249799. PMID: 33857216
4. Accuracy of citrulline, I-FABP and D-lactate in the diagnosis of acute mesenteric ischemia.  |  Nuzzo, A., et al. 2021. Sci Rep. 11: 18929. PMID: 34556697
5. Could I-FABP Be an Early Marker of Celiac Disease in Children with Type 1 Diabetes? Retrospective Study from the Tertiary Reference Centre.  |  Ochocińska, A., et al. 2022. Nutrients. 14: PMID: 35276772
6. The Value of Serum I-FABP Level in the Diagnosis of Acute Appendicitis.  |  Cakal, N., et al. 2022. Clin Lab. 68: PMID: 35536089
7. FABP4 and I-FABP Levels in Pregnant Women Are Associated with Body Mass Index but Not Gestational Diabetes.  |  Vorobjova, T., et al. 2022. J Diabetes Res. 2022: 1089434. PMID: 35647197
8. Intestinal Fatty Acid Binding Protein (I-FABP) as a Prognostic Marker in Critically Ill COVID-19 Patients.  |  Tyszko, M., et al. 2022. Pathogens. 11: PMID: 36558860
9. Exploring I-FABP, endothelin-1 and L-lactate as biomarkers of acute intestinal necrosis: a case-control study.  |  Straarup, D., et al. 2023. Scand J Gastroenterol. 58: 1359-1365. PMID: 37403410
10. I-FABP protein/mRNA and IL-6 as biomarkers of intestinal barrier dysfunction in neonates with necrotizing enterocolitis and SPF BALB/c mouse models.  |  Chen, J., et al. 2024. J Int Med Res. 52: 3000605241254788. PMID: 38867509

The preferred I-FABP antibody is I-FABP Antibody (E-9): sc-374482.