Molecular structure of Hydrochlorothiazide, CAS Number: 58-93-5
Hydrochlorothiazide (CAS 58-93-5)
Alternate Names:
Hypothiazide
Application:
Hydrochlorothiazide is a carbonic anhydrase inhibitor
CAS Number:
58-93-5
Purity:
≥98%
Molecular Weight:
297.74
Molecular Formula:
C7H8ClN3O4S2
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hydrochlorothiazide is a synthetic compound categorized under thiazide derivatives due to its chemical structure, which includes a sulfonamide group integral to its function. This group is crucial for the compound′s interaction with specific transport mechanisms within cellular systems, particularly affecting ion movement. In studies focused on fluid dynamics and electrolyte management within various biological and experimental systems, hydrochlorothiazide is utilized to explore the processes of ion exchange and fluid balance. Its ability to influence these mechanisms makes it a valuable agent in research settings, helping to elucidate the underlying principles of cellular transport and homeostasis. The stability and solubility characteristics of hydrochlorothiazide are of interest in the development of methods and materials that require precise control of ionic and fluid environments.
Hydrochlorothiazide (CAS 58-93-5) References
- Valsartan/hydrochlorothiazide: a review of its pharmacology, therapeutic efficacy and place in the management of hypertension. | Wellington, K. and Faulds, DM. 2002. Drugs. 62: 1983-2005. PMID: 12215069
- Valsartan/hydrochlorothiazide: a review of its use in the management of hypertension. | Wagstaff, AJ. 2006. Drugs. 66: 1881-901. PMID: 17040120
- Comparison of benazepril and other antihypertensive agents alone and in combination with the diuretic hydrochlorothiazide. | DeQuattro, V. 1991. Clin Cardiol. 14: IV28-32; discussion IV51-5. PMID: 1893639
- Antihypertensive efficacy of aliskiren: is hydrochlorothiazide an appropriate benchmark? | Messerli, FH. and Bangalore, S. 2009. Circulation. 119: 371-3. PMID: 19171867
- Valsartan/hydrochlorothiazide: pharmacology and clinical efficacy. | Kondrack, R. and Mohiuddin, S. 2009. Expert Opin Drug Metab Toxicol. 5: 1125-34. PMID: 19689218
- Efficacy of aliskiren/hydrochlorothiazide combination for the treatment of hypertension: a meta-analytical approach. | Morgado, MP., et al. 2011. Open Cardiovasc Med J. 5: 6-14. PMID: 21660247
- Telmisartan/Hydrochlorothiazide combination therapy for the treatment of hypertension: a pooled analysis in older and younger patients. | Kjeldsen, SE., et al. 2013. J Clin Hypertens (Greenwich). 15: 380-8. PMID: 23730986
- The pharmacokinetics of amiloride-hydrochlorothiazide combination in the young and elderly. | Ismail, Z., et al. 1989. Eur J Clin Pharmacol. 37: 167-71. PMID: 2792171
- Hydrochlorothiazide and risk of hearing disorder: a case series. | Belai, N., et al. 2018. J Med Case Rep. 12: 135. PMID: 29778098
- Vitamin B12 protects against DNA damage induced by hydrochlorothiazide. | Alzoubi, KH., et al. 2018. Saudi Pharm J. 26: 786-789. PMID: 30202218
- A persistent dyspnea induced by hydrochlorothiazide. | Kaabi, W., et al. 2019. Therapie. 74: 498-499. PMID: 31023617
- Hydrochlorothiazide-amiloride in the treatment of congenital nephrogenic diabetes insipidus. | Alon, U. and Chan, JC. 1985. Am J Nephrol. 5: 9-13. PMID: 3970081
- Hydrochlorothiazide-induced water intoxication in myxedema. | Mataverde, AQ., et al. 1974. JAMA. 230: 1014-5. PMID: 4479534
Inhibitor of:
αENaC, βENaC, δENaC, γENaC, AE3, ANG III, apoA-V, AQP12A, AQP2, C20orf111, C4ST-2, CA XII, CA XIII, Carbonic Anhydrases, CLCA3_Clac3, ESPNL, Fibrocystin, Fibrocystin L, FXYD7, GPR89, KCC1, MIP-T3, MMGT1, Mmgt2, Na+ CP type XIα, NCBE, NCKX2, NCKX4, NHEDC1, NHEDC2, NKAIN1, NPT1, Olfr427, Olr193, Olr210, Olr213, Olr252, Olr27, Olr419, Olr808, OSR1, PIPES, PKD2, Polycystin-1L2, Polycystin-L2, Relaxin 1, RENBP, SLC12A8, SLC12A9, SLC17A (solute carrier family 17), SLC17A2, SLC26A11, SLC26A6, SLC38A11, SLC41A1, TRMP6, WNK1, and WNK3.Activator of:
Ace3, ANG III, ATP13A3, Barttin, CA I, CA XV, KLHL3, Na+ CP type Iα, Na+ CP type IIIβ, NCCT, NHE-5, NHE-7, NHE-9, NKAIN1, ORMDL2, OTOP3, OXSR1, PEPT2, Renin, Renin-1, RhBG, SLC10A5, SLC26A8, SLC35E4, SLC41A3, SLC45A4, SLC46A3, SLC4A4, Sodium Chloride, TMEM63B, TTYH1, V3R 11, WNK1, and WNK2.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hydrochlorothiazide, 5 g | sc-207738 | 5 g | $55.00 | |||
Hydrochlorothiazide, 25 g | sc-207738A | 25 g | $240.00 | |||
Hydrochlorothiazide, 50 g | sc-207738B | 50 g | $333.00 | |||
Hydrochlorothiazide, 100 g | sc-207738C | 100 g | $562.00 | |||
Hydrochlorothiazide, 250 g | sc-207738D | 250 g | $988.00 |