Molecular structure of Hematin, CAS Number: 15489-90-4
Hematin (CAS 15489-90-4)
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Alternate Names:
Hematin is also known as Haematin.
Application:
Hematin is an iron-containing porphyrin that was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens.
CAS Number:
15489-90-4
Molecular Weight:
633.49
Molecular Formula:
C34H33N4O5Fe
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
* Refer to Certificate of Analysis for lot specific data.
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SDS & Certificate of Analysis
Hematin is an iron-containing porphyrin that was used in a study to test in vitro activities of the Rx-01 oxazolidinones against hospital and community pathogens. Hematin forms when heme is oxidized, typically involving the iron present in the heme changing from a ferrous (Fe^2+) to a ferric (Fe^3+) state. The iron in hematin is in the ferric (Fe^3+) oxidation state, which affects its ability to bind oxygen and other ligands compared to the ferrous iron in heme. This state makes hematin unable to bind oxygen, differentiating it from heme in functional hemoglobin. It was also used in a study to test in-vitro bacterial identification using fluorescence spectroscopy with an optical fiber system.
Hematin (CAS 15489-90-4) References
- Cloning and heterologous expression of hematin-dependent catalase produced by Lactobacillus plantarum CNRZ 1228. | Abriouel, H., et al. 2004. Appl Environ Microbiol. 70: 603-6. PMID: 14711694
- Resonance Raman in Vitro Detection and Differentiation of the Nitrite-Induced Hemoglobin Adducts in Functional Human Red Blood Cells. | Marzec, KM., et al. 2016. J Phys Chem B. 120: 12249-12260. PMID: 27934219
- Database of Absorption and Fluorescence Spectra of >300 Common Compounds for use in PhotochemCAD. | Taniguchi, M. and Lindsey, JS. 2018. Photochem Photobiol. 94: 290-327. PMID: 29166537
- Raman imaging of heme metabolism in situ in macrophages and Kupffer cells. | Dybas, J., et al. 2018. Analyst. 143: 3489-3498. PMID: 29951676
- Purification and characterization of three distinct glutathione transferases from mouse liver. | Warholm, M., et al. 1986. Biochemistry. 25: 4119-25. PMID: 3091071
- Design, synthesis, in-vitro, in-vivo and in-silico studies of pyrrolidine-2,5-dione derivatives as multitarget anti-inflammatory agents. | Jan, MS., et al. 2020. Eur J Med Chem. 186: 111863. PMID: 31740050
- Synthesis, in-vitro, in-vivo anti-inflammatory activities and molecular docking studies of acyl and salicylic acid hydrazide derivatives. | Munir, A., et al. 2020. Bioorg Chem. 104: 104168. PMID: 32947133
- Phytochemical profiling of bioactive compounds, anti-inflammatory and analgesic potentials of Habenaria digitata Lindl.: Molecular docking based synergistic effect of the identified compounds. | Mahnashi, MH., et al. 2021. J Ethnopharmacol. 273: 113976. PMID: 33647424
- Tailoring the substitution pattern of Pyrrolidine-2,5-dione for discovery of new structural template for dual COX/LOX inhibition. | Sadiq, A., et al. 2021. Bioorg Chem. 112: 104969. PMID: 34023639
- GC-MS Analysis and Various In Vitro and In Vivo Pharmacological Potential of Habenaria plantaginea Lindl. | Mahnashi, MH., et al. 2022. Evid Based Complement Alternat Med. 2022: 7921408. PMID: 35399645
- Comparative in-vitro anti-inflammatory, anticholinesterase and antidiabetic evaluation: computational and kinetic assessment of succinimides cyano-acetate derivatives. | Pervaiz, A., et al. 2022. J Biomol Struct Dyn. 1-14. PMID: 35507043
- Diclofenac derivatives as concomitant inhibitors of cholinesterase, monoamine oxidase, cyclooxygenase-2 and 5-lipoxygenase for the treatment of Alzheimer's disease: synthesis, pharmacology, toxicity and docking studies. | Javed, MA., et al. 2022. RSC Adv. 12: 22503-22517. PMID: 36105972
- Bacterial dehalogenases: biochemistry, genetics, and biotechnological applications. | Fetzner, S. and Lingens, F. 1994. Microbiol Rev. 58: 641-85. PMID: 7854251
Inhibitor of:
GST, and GSTT2B.Activator of:
Ferrochelatase, GRXCR1, HMBOX1, HRI, PBGD, and PPOX.Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Hematin, 250 mg | sc-207729 | 250 mg | $73.00 | |||
Hematin, 1 g | sc-207729A | 1 g | $80.00 | |||
Hematin, 10 g | sc-207729C | 10 g | $734.00 | |||
Hematin, 100 g | sc-207729D | 100 g | $5728.00 |