Fli-1 Antibody (23D10): sc-134223
- Fli-1 Antibody (23D10) is a mouse monoclonal IgG1 provided at 200 µg/ml
- raised against the N-terminus of Fli-1 protein of human origin
- recommended for detection of Fli-1 of human origin by WB, IP, IF and ELISA; non cross-reactive with mouse Fli-1
- TransCruz reagent for ChIP application (sc-134223 X, 200 µg/0.1 ml)
- See Fli-1 (F-12): sc-365294 for Fli-1 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fli-1 Antibody (23D10). This work is in progress.
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Fli-1 Antibody (23D10) is a mouse monoclonal IgG1 antibody that detects Fli-1 in human samples through applications such as western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), and enzyme-linked immunosorbent assay (ELISA). Fli-1 is a member of the Ets family of transcription factors, which play crucial roles in various biological processes, including hematopoiesis, angiogenesis, and cell differentiation. Fli-1 is primarily located in the nucleus, where Fli-1 binds to specific DNA sequences to regulate gene expression. This nuclear localization enables Fli-1 to interact with other transcriptional regulators and chromatin remodeling complexes, thereby influencing the transcription of target genes involved in cell growth and development. Additionally, Fli-1 has been implicated in the pathogenesis of certain cancers, making Fli-1 an important target for research in cancer biology. Anti-Fli-1 antibody (23D10) provides a reliable tool for studying the expression and function of this critical protein in various cellular contexts.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Fli-1 Antibody (23D10) References:
- The role of Fli-1 in normal cell function and malignant transformation. | Truong, AH. and Ben-David, Y. 2000. Oncogene. 19: 6482-9. PMID: 11175364
- Acetylation impacts Fli-1-driven regulation of granulocyte colony stimulating factor. | Lennard Richard, ML., et al. 2016. Eur J Immunol. 46: 2322-2332. PMID: 27431361
- Overexpression of Fli-1 in astrocytoma is associated with poor prognosis. | Tsai, HP., et al. 2017. Oncotarget. 8: 29174-29186. PMID: 28418872
- EWS-FLI-1 creates a cell surface microenvironment conducive to IGF signaling by inducing pappalysin-1. | Jayabal, P., et al. 2017. Genes Cancer. 8: 762-770. PMID: 29321818
- Fli-1 promotes proliferation and upregulates NANOGP8 expression in T-lymphocyte leukemia cells. | Park, SW., et al. 2020. Biochimie. 168: 1-9. PMID: 31626853
- FLI-1 mediates tumor suppressor function via Klotho signaling in regulating CRC. | Xie, B., et al. 2020. Cell Biol Int. 44: 1514-1522. PMID: 32196848
- Interplay between FLI-1 and the LDB1 complex in murine erythroleukemia cells and during megakaryopoiesis. | Giraud, G., et al. 2021. iScience. 24: 102210. PMID: 33733070
- Transcription factor Fli-1 impacts the expression of CXCL13 and regulates immune cell infiltration into the kidney in MRL/lpr mouse. | Sato, S., et al. 2023. Lupus Sci Med. 10: PMID: 37094946
- FLI-1 is expressed in a wide variety of hematolymphoid neoplasms: a special concern in the differential diagnosis. | Cho, U., et al. 2024. Clin Exp Med. 24: 18. PMID: 38280044
- TIMP-1 Promotes Expression of MCP-1 and Macrophage Migration by Inducing Fli-1 in Experimental Liver Fibrosis. | Huang, X., et al. 2024. J Clin Transl Hepatol. 12: 634-645. PMID: 38993513
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fli-1 Antibody (23D10) | sc-134223 | 200 µg/ml | $322.00 | |||
Fli-1 Antibody (23D10) X | sc-134223 X | 200 µg/0.1 ml | $322.00 |