m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for FKBP2 Antibody (D-9) for WB and IHC(P) applications. This reagent is now offered in a bundle with FKBP2 Antibody (D-9) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FKBP2 Antibody (D-9) is a high quality monoclonal FKBP2 antibody (also designated FKBP13 antibody) suitable for the detection of the FKBP2 protein of mouse, rat and human origin. FKBP2 Antibody (D-9) is available as both the non-conjugated anti-FKBP2 antibody form, as well as multiple conjugated forms of anti-FKBP2 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. FKBP2 (FK506-binding protein 2), also known as PPIase (Peptidyl-prolyl cis-trans isomerase) and FKBP13 (13 kDa FKBP), is a 142 amino acid enzyme that accelerates the folding of proteins. Specifically, FKBP2 catalyzes the cis-trans isomerization of imidic peptide bonds in oligopeptides. Localized to the endoplasmic reticular membrane, FKBP2 is predominantly expressed in thymus and T-cells. FKBP2 is an immunophilin, an intracellular receptor that is inhibited by immunosuppressant drugs such as FK506 and rapamycin. BIG1, a guanine nucleotide exchange factor, and the C-terminus of 4.1G, a protein that stabilizes spectrin-actin binding, interact with FKBP2. The gene encoding FKBP2 maps to human chromosome 11, which houses over 1,400 genes and comprises nearly 4% of the human genome. Jervell and Lange-Nielsen syndrome, Jacobsen syndrome, Niemann-Pick disease, hereditary angioedema and Smith-Lemli-Opitz syndrome are associated with defects in genes that maps to chromosome 11.
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