m-IgGκ BP-HRP (mouse IgGκ binding protein-HRP) is the preferred detection reagent for FKBP11 Antibody (D-3) for WB applications. This reagent is now offered in a bundle with FKBP11 Antibody (D-3) (see ordering information below). For additional m-IgGκ BP conjugates see our complete list of Mouse IgG Binding Proteins.
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FKBP11 Antibody (D-3) is a high quality monoclonal FKBP11 antibody (also designated FKBP19 antibody) suitable for the detection of the FKBP11 protein of mouse, rat and human origin. FKBP11 Antibody (D-3) is available as both the non-conjugated anti-FKBP11 antibody form, as well as multiple conjugated forms of anti-FKBP11 antibody, including agarose, HRP, PE, FITC and multiple Alexa Fluor® conjugates. The immunophilins are a highly conserved family of cis-trans peptidyl-prolyl isomerases that bind to and mediate the effects of immunosuppressive drugs, such as cyclosporin, FK506 and rapamycin. Immunophilins have also been implicated in protein folding and trafficking within the endoplasmic reticulum (ER). FKBP11 (FK506-binding protein 11), also known as FKBP19 or peptidyl-prolyl cis-trans isomerase FKBP11, is a 201 amino acid single-pass membrane protein belonging to the FKBP-type PPIase family, a group of proteins known to catalyze the folding of proline-containing polypeptides. Containing one PPIase FKBP-type domain, FKBP11 is expressed in secretory tissues such as pancreas, pituitary, stomach, lymph node and salivary gland, and is encoded by a gene that maps to human chromosome 12q13.12. FK506 and rapamycin are known to inhibit FKBP11′s peptidyl-prolyl isomerase activity.
For Research Use Only. Not Intended for Diagnostic or Therapeutic Use.
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