Fer Antibody (2358C3a): sc-81272
- Fer Antibody (2358C3a) is a mouse monoclonal IgG1, cited in 1 publications, provided at 100 µg/ml
- raised against a recombinant protein corresponding to an internal region of Fer of human origin
- recommended for detection of Fer of mouse, rat and human origin by WB and IP
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Fer Antibody (2358C3a). This work is in progress.
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Fer Antibody (2358C3a) is a mouse monoclonal IgG1 antibody that detects Fer in mouse, rat, and human samples through applications such as western blotting (WB) and immunoprecipitation (IP). Fer is a non-receptor protein-tyrosine kinase belonging to the Fes/Fps family, which is characterized by its unique SH2 domain and its role in mediating signaling pathways associated with receptor tyrosine kinases and cytokine receptors. Fer (2358C3a) antibody enables researchers to study Fer′s regulation of various cellular processes, including insulin signaling and cell-cell communication, which are crucial for maintaining normal physiological functions. Notably, Fer assembles into homotrimers in vivo through conserved coiled-coil domains, allowing for autophosphorylation that modulates its activity and function. This dynamic regulation is essential for Fer′s involvement in critical processes such as G1 progression and the pathogenesis of human prostatic proliferative diseases. Anti-Fer antibody (2358C3a) helps researchers gain valuable insights into the intricate signaling mechanisms mediated by Fer, furthering our understanding of its role in health and disease.
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Fer Antibody (2358C3a) References:
- FES/FER kinase signaling in hematopoietic cells and leukemias. | Craig, AW. 2012. Front Biosci (Landmark Ed). 17: 861-75. PMID: 22201778
- Targeting FER Kinase Inhibits Melanoma Growth and Metastasis. | Ivanova, IA., et al. 2019. Cancers (Basel). 11: PMID: 30909648
- FER promotes cell migration via regulating JNK activity. | Li, P., et al. 2019. Cell Prolif. 52: e12656. PMID: 31264309
- FER Regulated by miR-206 Promotes Hepatocellular Carcinoma Progression via NF-κB Signaling. | Ding, W., et al. 2021. Front Oncol. 11: 683878. PMID: 34295819
- FER regulates endosomal recycling and is a predictor for adjuvant taxane benefit in breast cancer. | Tavares, S., et al. 2022. Cell Rep. 39: 110584. PMID: 35385742
- The Fer tyrosine kinase protects sperm from spontaneous acrosome reaction. | Grinshtain, E., et al. 2022. Dev Biol. 487: 24-33. PMID: 35439527
- FER-mediated phosphorylation and PIK3R2 recruitment on IRS4 promotes AKT activation and tumorigenesis in ovarian cancer cells. | Zhang, Y., et al. 2022. Elife. 11: PMID: 35550247
- SKOR1 mediates FER kinase-dependent invasive growth of breast cancer cells. | Sluimer, LM., et al. 2023. J Cell Sci. 136: PMID: 36620935
- Fer and FerT: A New Regulatory Link between Sperm and Cancer Cells. | Nir, U., et al. 2023. Int J Mol Sci. 24: PMID: 36982326
- FER-like iron deficiency-induced transcription factor (FIT) accumulates in nuclear condensates. | Trofimov, K., et al. 2024. J Cell Biol. 223: PMID: 38393070
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Fer Antibody (2358C3a) | sc-81272 | 100 µg/ml | $339.00 |