FANK1 Antibody (E-5): sc-398057

FANK1 Antibody (E-5) is a mouse monoclonal IgG1 antibody that detects FANK1 in mouse, rat, and human samples through various applications including western blotting (WB), immunoprecipitation (IP), immunofluorescence (IF), immunohistochemistry, and enzyme-linked immunosorbent assay (ELISA). FANK1, also known as HSD13, is a 345 amino acid protein predominantly expressed in the nucleus and cytoplasm of testis-specific cells, particularly in pachytene spermatocytes and round spermatids. FANK1 features six ankyrin repeats and a single fibronectin type-III domain, which are crucial for function as a transcription factor, suggesting a role in regulating gene expression during spermatogenesis. FANK1 undergoes alternative splicing to produce three distinct isoforms, which may have different regulatory roles in testicular development. The gene encoding FANK1 is located on human chromosome 10, a region that harbors over 800 genes and is significant for association with various genetic conditions, including Cowden syndrome, which is linked to mutations in the tumor suppressor gene PTEN. FANK1′s ability to bind DNA highlights importance in cellular processes, particularly in the context of male fertility and potential implications in cancer biology, making anti-FANK1 antibody (E-5) an essential tool for researchers studying these critical areas.

The preferred FANK1 antibody is FANK1 Antibody (F-5): sc-398026.