EBV gp250/350 Envelope Protein Antibody (0221): sc-57724

EBV gp250/350 Envelope Protein Antibody (0221) is a mouse monoclonal IgG1 antibody that detects the EBV gp250/350 Envelope protein of Epstein-Barr Virus origin by western blotting (WB) and immunofluorescence (IF). Anti-EBV gp250/350 Envelope antibody (0221) is available as a non-conjugated format. EBV gp250/350 Envelope protein plays a pivotal role in viral infection by binding to complement receptor 2 (CR2) on human B cells, facilitating viral entry. This interaction initiates infection and influences immune response, potentially leading to clinical manifestations including infectious mononucleosis. Understanding EBV gp250/350 Envelope protein function remains essential for developing therapeutic strategies and vaccines against EBV-related diseases. EBV gp250/350 Envelope protein expression occurs on virion envelope and virus-producing cells, making EBV gp250/350 Envelope protein (0221) antibody valuable for research and diagnostic applications in Epstein-Barr Virus studies.

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EBV gp250/350 Envelope Protein Antibody (0221) References:

1. Epstein-Barr virus envelope glycoprotein gp350 induces NF-kappaB activation and IL-1beta synthesis in human monocytes-macrophages involving PKC and PI3-K.  |  D'Addario, M., et al. 1999. FASEB J. 13: 2203-13. PMID: 10593868
2. Binding of the Epstein-Barr virus major envelope glycoprotein gp350 results in the upregulation of the TNF-alpha gene expression in monocytic cells via NF-kappaB involving PKC, PI3-K and tyrosine kinases.  |  D'Addario, M., et al. 2000. J Mol Biol. 298: 765-78. PMID: 10801347
3. Infection of human lung fibroblasts with Epstein-Barr virus causes increased IL-1beta and bFGF production.  |  Adachi, H., et al. 2001. Exp Lung Res. 27: 157-71. PMID: 11258803
4. Roles of Epstein-Barr virus glycoproteins gp350 and gp25 in the infection of human epithelial cells.  |  Maruo, S., et al. 2001. J Gen Virol. 82: 2373-2383. PMID: 11562531
5. The crystal structure of human CD21: Implications for Epstein-Barr virus and C3d binding.  |  Prota, AE., et al. 2002. Proc Natl Acad Sci U S A. 99: 10641-6. PMID: 12122212
6. Epstein-Barr virus (EBV) glycoprotein gp350 expressed on transfected cells resistant to natural killer cell activity serves as a target antigen for EBV-specific antibody-dependent cellular cytotoxicity.  |  Khyatti, M., et al. 1991. J Virol. 65: 996-1001. PMID: 1846213
7. Identification of an epitope in the major envelope protein of Epstein-Barr virus that mediates viral binding to the B lymphocyte EBV receptor (CR2).  |  Nemerow, GR., et al. 1989. Cell. 56: 369-77. PMID: 2464439
8. Vero cell-expressed Epstein-Barr virus (EBV) gp350/220 protects marmosets from EBV challenge.  |  Emini, EA., et al. 1989. J Med Virol. 27: 120-3. PMID: 2537882

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-EBV gp250/350 Envelope Protein Antibody (0221) has 6 citations in a variety of scientific publications.

Primary antibodies for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

EBV gp250/350 Envelope Protein Antibody (0221) Specifications

Alternate Product Name: EBV gp250/350 Envelope Protein

Product Clone Name: 0221

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: EBV gp350 Envelope Protein

Epitope Species: Epstein-Barr virus

Product Reactivity/Detection: EBV gp250/350 Envelope Protein

Species Reactivity/Detection: Epstein-Barr Virus

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IF

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 0.1% gelatin

Research Citations: 6 citations in various scientific publications

Available Conjugates/Forms for EBV gp250/350 Envelope Protein Antibody (0221): N/A