E2F-4 Antibody (WUF11): sc-56669
- E2F-4 Antibody (WUF11) is a mouse monoclonal IgG1 κ, cited in 2 publications, provided at 200 µg/ml
- raised against full length E2F-4 of human origin
- recommended for detection of E2F-4 of mouse, rat and human origin by WB and IP
- See E2F-4 (D-7): sc-398543 for E2F-4 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- m-IgG Fc BP-HRP, m-IgG1 BP-HRP and m-IgGκ BP-HRP are the preferred secondary detection reagents for E2F-4 Antibody (WUF11) for WB applications. These reagents are now offered in bundles with E2F-4 Antibody (WUF11) (see ordering information below).
E2F-4 Antibody (WUF11) is a mouse monoclonal IgG1 antibody that detects E2F-4 in mouse, rat, and human samples through western blotting (WB) and immunoprecipitation (IP) applications. E2F-4 is a crucial member of the E2F family of transcription factors, which play a significant role in regulating the cell cycle, particularly during the transition from G1 phase to S phase. This regulation is vital for proper cell proliferation and differentiation, as dysregulation of E2F activity can lead to uncontrolled cell growth and is often implicated in various cancers. E2F-4 forms heterodimers with DP-1 protein, creating an active transcriptional regulatory complex that binds to specific DNA sequences to activate or repress target genes involved in cell cycle progression. E2F-4′s interaction with other proteins, including retinoblastoma (Rb) protein, further underscores E2F-4′s importance in cell cycle control, as Rb acts as a tumor suppressor by inhibiting E2F activity when unphosphorylated. The dynamic interplay between E2F-4 and Rb, along with other regulatory proteins, highlights the complexity of cell cycle regulation and the potential consequences of disruption, making E2F-4 a critical target for research in cancer biology and therapeutic interventions.
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
E2F-4 Antibody (WUF11) | sc-56669 | 200 µg/ml | $322.00 | |||
E2F-4 Antibody (WUF11): m-IgG Fc BP-HRP Bundle | sc-537113 | 200 µg Ab; 10 µg BP | $361.00 | |||
E2F-4 Antibody (WUF11): m-IgGκ BP-HRP Bundle | sc-534305 | 200 µg Ab; 40 µg BP | $361.00 | |||
E2F-4 Antibody (WUF11): m-IgG1 BP-HRP Bundle | sc-545011 | 200 µg Ab; 20 µg BP | $361.00 |