D-myo-Inositol-1,3,4,5,6-pentaphosphate, ammonium salt MF: C6H17O21P5•10NH4
MW: 760.4
One of the many inositol phosphate isomers that act as small, soluble second messengers in the transmission of cellular signals.

D-myo-Inositol-1,3,4,5,6-pentaphosphate, ammonium salt

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別名: Ins(1,3,4,5,6)P5
アプリケーション: D-myo-Inositol-1,3,4,5,6-pentaphosphate, ammonium salt is one of the many inositol phosphate isomers that act as small, soluble second messengers in the
Molecular Weight: 760.4
Molecular Formula: C6H17O21P510NH4
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* Refer to Certificate of Analysis for lot specific data (including water content).

Inositol-1,3,4,5,6-pentaphosphate (Ins(1,3,4,5,6)P5) is one of many inositol phosphate isomers that act as soluble second messengers in the transmission of cellular signals. Ins(1,3,4,5,6)P5 binds to the PH domain of Grp1 with a Kd of 590 nM


参考文献

1 Berridge, M.J. Inositol trisphosphate and calcium signalling. Nature 361 315-325 (1993). 2 Majerus, P.W. Inositol phosphate biochemistry. Annu Rev Biochem 61 225-250 (1992). 3 Shears, S.B. The versatility of inositol phosphates as cellular signals. Biochim Biophys Acta 1436 49-67 (1998). 4 Piccolo, E., Vignati, S., Maffucci, T., et al. Inositol pentakisphosphate promotes apoptosis through the PI 3-K/Akt pathway. Oncogene 23 1754-1765 (2004). 5 Maffucci, T., Piccolo, E., Cumashi, A., et al. Inhibition of the phosphatidylinositol 3-kinase/Akt pathway by inositol pentakisphosphate results in antiangiogenic and antitumor effects. Cancer Res 65(18) 8339-8349 (2005). 6 Kavran, J.M., Klein, D.E., Lee, A., et al. Specificity and promiscuity in phosphoinositide binding by pleckstrin homology domains. J Biol Chem 273(46) 30497-30508 (1998).

Appearance :
Lyophilized powder
Physical State :
Solid
保存方法 :
Store at -20° C
試験・研究用以外には使用しないでください。 臨床及び体外診断には使用できません。
SMILES :
O[[email protected]@H]1[[email protected]](OP([O])([O-])=O)[[email protected]@H](O[P+]([O-])([O-])=O)[[email protected]](OP([O])([O-])=O)[[email protected]@H](OP([O-])([O-])=O)[[email protected]@H]1OP([O])([O-])=O.[NH4+].[NH4+].[NH4+].[NH4].[NH4].[NH4+].[NH4+].[NH4].[NH4+].[NH4]

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