D,L N-Desmethyl Venlafaxine (CAS 149289-30-5)
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D,L N-Desmethyl Venlafaxine is a metabolite of Venlafaxine (sc-201102). Venlafaxine is a derivative of phenylethylamine which is reported to facilitate neurotransmission within the central nervous system via blocking the presynaptic reuptake of neuroamines such as serotonin (5-hydroxytryptamine 5-HT) and noradrenaline (norepinephrine). Velanfaxine is also reported to be a weak inhibitor of dopamine reuptake. In vitro studies indicate that Venlafaxine does not demonstrate significant activity for muscarinic, histaminergic or alpha-1 adrenergic receptors. The metabolism of venlafaxine is reported to occur by cytochrome P450 (CYP) enzyme CYP2D6 yielding O-desmethylvenlafaxine. A lesser metabolite, N-desmethylvenlafaxine is produced by CYP3A4. D,L N-Desmethyl Venlafaxine exerts its effects by inhibiting the reuptake of both serotonin and norepinephrine, similar to venlafaxine. By blocking the reuptake of these neurotransmitters, it increases their concentrations in the brain, which can help alleviate symptoms of depression and anxiety.
D,L N-Desmethyl Venlafaxine (CAS 149289-30-5) References
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Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
D,L N-Desmethyl Venlafaxine, 5 mg | sc-207483 | 5 mg | $320.00 |