Cytokeratin 5/14 Antibody (LH8): sc-53259
- Cytokeratin 5/14 Antibody (LH8) is a mouse monoclonal IgM κ provided at 200 µg/ml
- raised against foreskin keratinocytes of human origin
- recommended for detection of Cytokeratin 5/14 of human origin by IF
- See Cytokeratin 14 (LL001): sc-53253 for Cytokeratin 5/14 antibody conjugates, including AC, HRP, FITC, PE, Alexa Fluor® 488, 594, 647, 680 and 790.
- At present, we have not yet completed the identification of the preferred secondary detection reagent(s) for Cytokeratin 5/14 Antibody (LH8). This work is in progress.
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Cytokeratin 5/14 Antibody (LH8) is a mouse monoclonal IgM antibody that detects Cytokeratin 5/14 in human samples through immunofluorescence (IF) applications. Cytokeratin 5 and Cytokeratin 14 are crucial components of the cytoskeletal structure in epithelial cells, primarily found in the basal layer of stratified squamous epithelia, such as the skin and the lining of the esophagus. Anti-Cytokeratin 5/14 antibody (LH8) helps identify these proteins that maintain structural integrity and mechanical resilience of tissues, particularly in response to physical stress and injury. Cytokeratin 5 and Cytokeratin 14 interact with other cytokeratins and proteins, such as desmoplakin, playing a significant role in forming desmosomes, which are essential for cell-cell adhesion. This interaction supports the overall architecture of epithelial tissues and contributes to signaling pathways that regulate cell proliferation and differentiation. Cytokeratin 5/14 (LH8) monoclonal antibody serves as a valuable marker in diagnosing various epithelial tumors, making anti-Cytokeratin 5/14 antibody (LH8) an invaluable tool for researchers and clinicians in understanding epithelial biology and pathology.
Alexa Fluor® is a trademark of Molecular Probes Inc., OR., USA
LI-COR® and Odyssey® are registered trademarks of LI-COR Biosciences
Cytokeratin 5/14 Antibody (LH8) References:
- Distribution of p63, cytokeratins 5/6 and cytokeratin 14 in 51 normal and 400 neoplastic human tissue samples using TARP-4 multi-tumor tissue microarray. | Reis-Filho, JS., et al. 2003. Virchows Arch. 443: 122-32. PMID: 12884041
- Cytokeratin 5-Positive Cells Represent a Therapy Resistant subpopulation in Epithelial Ovarian Cancer. | Corr, BR., et al. 2015. Int J Gynecol Cancer. 25: 1565-73. PMID: 26495758
- Cytokeratin 5/6 and P63 immunophenotype of thyroid lymphoepithelial complexes. | Handra-Luca, A. and Dragoescu, E. 2016. Ann Diagn Pathol. 23: 58-61. PMID: 27130144
- Correlation between salivary estrogen levels and oral epithelial cytokeratin 5 expression. | Handajani, J., et al. 2020. F1000Res. 9: 186. PMID: 32399205
- Cytokeratin 5 determines maturation of the mammary myoepithelium. | Deckwirth, V., et al. 2021. iScience. 24: 102413. PMID: 34007958
- Cytokeratin 5 and cytokeratin 20 inversely correlate with tumour grading in Ta non-muscle-invasive bladder cancer. | Muilwijk, T., et al. 2021. J Cell Mol Med. 25: 7890-7900. PMID: 34184816
- Cytokeratin 5 and cytokeratin 6 expressions are unconnected in normal and cancerous tissues and have separate diagnostic implications. | Völkel, C., et al. 2022. Virchows Arch. 480: 433-447. PMID: 34559291
- Visualizing Cytokeratin-14 Levels in Basal-Like Breast Cancer via ImmunoSPECT Imaging. | Ji, H., et al. 2022. Mol Pharm. 19: 3542-3550. PMID: 35285645
- Clinicopathological features of cytokeratin 5-positive pulmonary adenocarcinoma. | Terada, K., et al. 2023. Histopathology. 82: 439-453. PMID: 36239561
- In vivo tracing of the Cytokeratin 14 lineages using self-cleaving guide RNAs and CRISPR/Cas9. | Tiyaboonchai, A., et al. 2023. Dev Biol. 504: 120-127. PMID: 37813160
Ordering Information
| Product Name | Catalog # | UNIT | Price | Qty | FAVORITES | |
Cytokeratin 5/14 Antibody (LH8) | sc-53259 | 200 µg/ml | $322.00 |