cyclin J Antibody (2126C1a): sc-81064

Cyclin J Antibody (2126C1a) is a mouse monoclonal IgG1 antibody that detects cyclin J protein of human origin by western blotting (WB) and immunoprecipitation (IP). Anti-cyclin J antibody (2126C1a) is available as a non-conjugated format. Cyclin J, encoded by the human gene CCNJ located on chromosome 10, is a 372 amino acid protein that plays a crucial role in regulating the cell cycle. Cyclin J belongs to the cyclin family and features a cyclin N-terminal domain, which is essential for interaction with cyclin-dependent kinases (Cdks). Formation of cyclin-Cdk complexes is vital for activation of Cdk′s protein kinase activity, driving cells through various stages of the cell cycle. Cyclin J is particularly important during early embryonic division cycles, where kinase activity is required for proper cell division and development. Cyclical concentrations ensure cells progress through the cell cycle in a regulated manner, with cyclin J levels fluctuating to facilitate timely activation and inactivation of Cdk activity. When cyclin J levels drop, detachment from Cdk occurs, effectively inhibiting kinase activity and ensuring cell cycle progression remains in check. This regulatory mechanism underscores cyclin J′s importance in maintaining cellular homeostasis and proper developmental processes.

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cyclin J Antibody (2126C1a) References:

1. Cyclin F regulates the nuclear localization of cyclin B1 through a cyclin-cyclin interaction.  |  Kong, M., et al. 2000. EMBO J. 19: 1378-88. PMID: 10716937
2. A role for cyclin J in the rapid nuclear division cycles of early Drosophila embryogenesis.  |  Kolonin, MG. and Finley, RL. 2000. Dev Biol. 227: 661-72. PMID: 11071782
3. A roller coaster ride with the mitotic cyclins.  |  Fung, TK. and Poon, RY. 2005. Semin Cell Dev Biol. 16: 335-42. PMID: 15840442
4. New insights for understanding the transcription-coupled repair pathway.  |  Sarasin, A. and Stary, A. 2007. DNA Repair (Amst). 6: 265-9. PMID: 17194629
5. Molecular mechanisms of skin aging: state of the art.  |  Makrantonaki, E. and Zouboulis, CC. 2007. Ann N Y Acad Sci. 1119: 40-50. PMID: 18056953
6. Human cyclin F.  |  Bai, C., et al. 1994. EMBO J. 13: 6087-98. PMID: 7813445

Monoclonal antibodies for mammalian and non-mammalian protein targets represent essentially all targets covered by polyclonal antibodies. Over 8,300 of our antibodies are offered as ImmunoCruz^® conjugates which eliminates the need for a secondary antibody.

Santa Cruz Biotechnology antibodies have over 360,000 research citations. Anti-cyclin J Antibody (2126C1a) has 0 citations in a variety of scientific publications.

Primary antibodies like Anti-cyclin J Antibody (2126C1a) for mammalian target proteins are recommended for the detection of a range of mammalian species, primarily of mouse, rat and human species. Many mammalian antibodies are also ideal for veterinary research and reactive with ovine, porcine, caprine, feline, canine, bovine and equine protein targets. Santa Cruz Biotechnology primary monoclonal antibodies are suitable for laboratory research applications and are not intended for diagnostic or therapeutic use.

cyclin J Antibody (2126C1a) Specifications

Alternate Product Name: cyclin J

Product Clone Name: 2126C1a

Classification: Primary Antibody

Clonality: Monoclonal Antibody

Antibody Isotype: IgG₁

Amino Acids:

Epitope Target: cyclin J

Epitope Species: human

Product Reactivity/Detection: cyclin J

Species Reactivity/Detection: human

Additional Mammalian Reactivity: N/A

Additional Non-Mammalian Reactivity: N/A

Applications: WB, IP

Vialing Information: Each vial contains 100 µg IgG₁ in 1.0 ml of PBS with < 0.1% sodium azide and 1.0% stabilizer protein

Research Citations: 0 citations in various scientific publications

Available Conjugates/Forms for cyclin J Antibody (2126C1a): N/A